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Details on Person MIA40:ERV1 (CHCHD4:GFER) oxidizes cysteine residues to cystine disulfide bonds

Class:Id	Reaction:1307802
_displayName	MIA40:ERV1 (CHCHD4:GFER) oxidizes cysteine residues to cystine disulfide bonds
_doRelease	TRUE
_timestamp	2023-11-06 06:21:13
authored	[InstanceEdit:1299488] May, B, 2011-05-23
catalystActivity	[CatalystActivity:1307805] protein-disulfide reductase activity of MIA40:ERV1 [mitochondrial intermembrane space]
compartment	[Compartment:17927] mitochondrial intermembrane space
created	[InstanceEdit:1307804] May, B, 2011-05-29
edited	[InstanceEdit:1299488] May, B, 2011-05-23
inferredFrom	[Reaction:1252260] MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds [Saccharomyces cerevisiae]
input	[CandidateSet:1307798] Substrates of MIA40:ERV1 [mitochondrial intermembrane space] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1307764] Augmenter of liver regeneration: a flavin-dependent sulfhydryl oxidase with cytochrome c reductase activity [LiteratureReference:1307757] The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency [LiteratureReference:1307746] Structure of the human sulfhydryl oxidase augmenter of liver regeneration and characterization of a human mutation causing an autosomal recessive myopathy [LiteratureReference:1307745] Functional and mutational characterization of human MIA40 acting during import into the mitochondrial intermembrane space [LiteratureReference:1307738] Multiple pathways for mitochondrial protein traffic [LiteratureReference:1307739] Multiple pathways for sorting mitochondrial precursor proteins [LiteratureReference:6800087] MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism [LiteratureReference:6800105] A small molecule inhibitor of redox-regulated protein translocation into mitochondria
modified	[InstanceEdit:1307807] May, B, 2011-05-29 [InstanceEdit:1480933] May, B, 2011-08-11 [InstanceEdit:1914221] D'Eustachio, P, 2011-11-01 [InstanceEdit:1977303] May, B, 2011-11-08 [InstanceEdit:2010553] May, B, 2011-11-22 [InstanceEdit:2108992] May, B, 2012-02-12 [InstanceEdit:2143820] May, B, 2012-02-26 [InstanceEdit:5257491] May, B, 2014-02-06 [InstanceEdit:6800101] May, Bruce, 2015-09-28 [InstanceEdit:6800113] May, Bruce, 2015-09-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9852700] May, Bruce, 2023-11-06
name	MIA40:ERV1 (CHCHD4:GFER) oxidizes cysteine residues to cystine disulfide bonds
output	[CandidateSet:1307799] Products of MIA40:ERV1 [mitochondrial intermembrane space] [Homo sapiens]
precedingEvent	[Reaction:1268022] TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space [Homo sapiens]
releaseDate	2012-03-13
reviewed	[InstanceEdit:1914221] D'Eustachio, P, 2011-11-01 [InstanceEdit:2108993] Endo, T, 2012-02-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2158279] R-HSA-1307802.4
summation	[Summation:1307727] Proteins are imported into the intermembrane space via the i...
(hasEvent)	[Pathway:1268020] Mitochondrial protein import [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9783991] Update Tracker - [Reaction:1307802] MIA40:ERV1 (CHCHD4:GFER) oxidizes cysteine residues to cystine disulfide bonds - v55:[addLiteratureReference, modifyText]
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