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Details on Person GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers

Class:Id	Reaction:1306969
_displayName	GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers
_doRelease	TRUE
_timestamp	2024-03-20 23:46:35
authored	[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:1306970] Orlic-Milacic, Marija, 2011-05-27
edited	[InstanceEdit:1972361] Matthews, L, 2011-11-07
input	[Complex:109797] GRB2-1:SOS1 [cytosol] [Homo sapiens] [DefinedSet:1963592] Phosphorylated ERBB2:ERBB4 heterodimers [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1358721] Signal transduction pathways induced by heregulin in MDA-MB-453 breast cancer cells
modified	[InstanceEdit:1358777] Orlic-Milacic, Marija, 2011-06-02 [InstanceEdit:1368193] Orlic-Milacic, Marija, 2011-06-30 [InstanceEdit:1474193] Orlic-Milacic, Marija, 2011-08-05 [InstanceEdit:1474296] Orlic-Milacic, Marija, 2011-08-05 [InstanceEdit:1963620] Orlic-Milacic, M, 2011-11-03 [InstanceEdit:1972367] Orlic-Milacic, M, 2011-11-04 [InstanceEdit:1972368] Orlic-Milacic, M, 2011-11-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9866055] Orlic-Milacic, Marija, 2024-03-20
name	GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers
negativePrecedingEvent	[NegativePrecedingEvent:9866044] Futile Cycle: ERBB2 promotes PTK6 autophosphorylation
output	[Complex:1306947] NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1963582] Trans-autophosphorylation of ERBB2 heterodimers [Homo sapiens] [Reaction:1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 [Homo sapiens] [Reaction:1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers [Homo sapiens] [Reaction:1963586] SRC family kinases phosphorylate ERBB2 [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1972347] Neckers, LM, 2011-11-11 [InstanceEdit:1972346] Xu, W, 2011-11-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016706] R-HSA-1306969.3
summation	[Summation:1358754] GRB2:SOS1 complex binds to phosphorylated tyrosine residue Y...
(hasEvent)	[Pathway:1963640] GRB2 events in ERBB2 signaling [Homo sapiens]
(precedingEvent)	[Reaction:1306972] RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers [Homo sapiens] [Reaction:5672965] RAS GEFs promote RAS nucleotide exchange [Homo sapiens]
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No pathways have been reviewed or authored by GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (1306969)