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Details on Person Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR

Class:Id	Reaction:1306965
_displayName	Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
_doRelease	TRUE
_timestamp	2024-07-16 19:49:20
authored	[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:1306964] Orlic-Milacic, Marija, 2011-05-27
edited	[InstanceEdit:1972361] Matthews, L, 2011-11-07
input	[Complex:1306958] EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] [Homo sapiens] [Complex:1806218] PIK3CA:PIK3R1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1358727] Blockade of epidermal growth factor- or heregulin-dependent ErbB2 activation with the anti-ErbB2 monoclonal antibody 2C4 has divergent downstream signaling and growth effects
modified	[InstanceEdit:1358773] Orlic-Milacic, Marija, 2011-06-02 [InstanceEdit:1370829] Orlic-Milacic, Marija, 2011-07-04 [InstanceEdit:1474296] Orlic-Milacic, Marija, 2011-08-05 [InstanceEdit:1963596] Orlic-Milacic, M, 2011-11-03 [InstanceEdit:1972362] Orlic-Milacic, M, 2011-11-04 [InstanceEdit:1972373] Orlic-Milacic, M, 2011-11-04 [InstanceEdit:8864009] Orlic-Milacic, Marija, 2016-03-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9915824] D'Eustachio, Peter, 2024-07-16
name	Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
output	[Complex:1306961] EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1306963] Binding of GRB2:GAB1 to p-ERBB2:p-EGFR [Homo sapiens] [Reaction:1963582] Trans-autophosphorylation of ERBB2 heterodimers [Homo sapiens] [Reaction:1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1972347] Neckers, LM, 2011-11-11 [InstanceEdit:1972346] Xu, W, 2011-11-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016098] R-HSA-1306965.4
summation	[Summation:1358769] Regulatory subunit p85 of PI3K (PIK3R1) binds GAB1 in comple...
(hasEvent)	[Pathway:1963642] PI3K events in ERBB2 signaling [Homo sapiens]
(normalReaction)	[Reaction:9664933] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K [Homo sapiens] [Reaction:9665415] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K [Homo sapiens]
(precedingEvent)	[Reaction:1306957] PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR [Homo sapiens] [Reaction:2316434] PI3K phosphorylates PIP2 to PIP3 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777606] Update Tracker - [Reaction:1306965] Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. - v70:[modifyText] [_UpdateTracker:9783086] Update Tracker - [Reaction:1306965] Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. - v57:[add_removeInput, add_removeOutput, modifyText]
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