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Details on Person Binding of GRB2:GAB1 to p-ERBB2:p-EGFR

Class:Id	Reaction:1306963
_displayName	Binding of GRB2:GAB1 to p-ERBB2:p-EGFR
_doRelease	TRUE
_timestamp	2024-03-20 23:45:53
authored	[InstanceEdit:1972370] Orlic-Milacic, M, 2011-11-04
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1306964] Orlic-Milacic, Marija, 2011-05-27
edited	[InstanceEdit:1972361] Matthews, L, 2011-11-07
input	[Complex:179849] GRB2:GAB1 [cytosol] [Homo sapiens] [CandidateSet:1963587] Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1358727] Blockade of epidermal growth factor- or heregulin-dependent ErbB2 activation with the anti-ErbB2 monoclonal antibody 2C4 has divergent downstream signaling and growth effects
modified	[InstanceEdit:1358772] Orlic-Milacic, Marija, 2011-06-02 [InstanceEdit:1474296] Orlic-Milacic, Marija, 2011-08-05 [InstanceEdit:1963596] Orlic-Milacic, M, 2011-11-03 [InstanceEdit:1972362] Orlic-Milacic, M, 2011-11-04 [InstanceEdit:1972373] Orlic-Milacic, M, 2011-11-04 [InstanceEdit:2006489] Orlic-Milacic, M, 2011-11-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9866055] Orlic-Milacic, Marija, 2024-03-20
name	Binding of GRB2:GAB1 to p-ERBB2:p-EGFR
negativePrecedingEvent	[NegativePrecedingEvent:9866036] Futile Cycle: ERBB2 promotes PTK6 autophosphorylation [NegativePrecedingEvent:9866025] Futile Cycle: PLCG1 phosphorylation by p-EGFR:p-ERBB2
output	[Complex:1306958] EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1963582] Trans-autophosphorylation of ERBB2 heterodimers [Homo sapiens] [Reaction:1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 [Homo sapiens] [Reaction:1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers [Homo sapiens] [Reaction:1963586] SRC family kinases phosphorylate ERBB2 [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1972347] Neckers, LM, 2011-11-11 [InstanceEdit:1972346] Xu, W, 2011-11-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016653] R-HSA-1306963.3
summation	[Summation:1358757] GAB1 in complex with GRB2 is recruited to activated ERBB2:EG...
(hasEvent)	[Pathway:1963642] PI3K events in ERBB2 signaling [Homo sapiens]
(normalReaction)	[Reaction:9664918] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:GAB1 [Homo sapiens] [Reaction:9665417] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind GRB2:GAB1 [Homo sapiens]
(precedingEvent)	[Reaction:1306965] Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777511] Update Tracker - [Reaction:1306963] Binding of GRB2:GAB1 to p-ERBB2:p-EGFR - v70:[modifyText]
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