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Details on Person UniProt:A6ZKL2 MAP2
| Class:Id | ReferenceGeneProduct:1300697 |
|---|---|
| _chainChangeLog | chain:1-421 added on Sat February 7 2015 |
| _displayName | UniProt:A6ZKL2 MAP2 |
| _timestamp | 2023-11-03 15:18:20 |
| chain | chain:1-421 |
| checksum | 206E9651D88925A8 |
| comment | FUNCTION Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).CATALYTIC ACTIVITY Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.COFACTOR Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.SUBCELLULAR LOCATION Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily. |
| created | [InstanceEdit:1300696] Yung, CK |
| description | recommendedName: fullName evidence="2"Methionine aminopeptidase 2 shortName evidence="2"MAP 2 shortName evidence="2"MetAP 2 ecNumber evidence="2"3.4.11.18 alternativeName: fullName evidence="2"Peptidase M |
| geneName | MAP2 SCY_0132 |
| identifier | A6ZKL2 |
| isSequenceChanged | FALSE |
| keyword | Aminopeptidase Cytoplasm Hydrolase Metal-binding Phosphoprotein Protease |
| modified | [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | MAP2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | MAP2_YEAS7 |
| sequenceLength | 421 |
| species | [Species:68322] Saccharomyces cerevisiae |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:A6ZKL2 MAP2 (1300697)
