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Details on Person SRC phosphorylates SPRY2 on Y55 and Y227

Class:Id	Reaction:1295609
_displayName	SRC phosphorylates SPRY2 on Y55 and Y227
_doRelease	TRUE
_timestamp	2024-01-04 16:55:48
authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
catalystActivity	[CatalystActivity:179862] protein tyrosine kinase activity of SRC-1 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:1295600] Rothfels, K, 2011-05-17
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:934550] PP2A(A:C):SPRY2 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:188712] FRS2-dependent SRC activation is required for fibroblast growth factor receptor-induced phosphorylation of Sprouty and suppression of ERK activity [LiteratureReference:1268103] Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function [LiteratureReference:934625] Phosphorylation of carboxyl-terminal tyrosines modulates the specificity of Sprouty-2 inhibition of different signaling pathways [LiteratureReference:188721] Regulation of sprouty stability by Mnk1-dependent phosphorylation
modified	[InstanceEdit:1498860] Rothfels, K, 2011-08-18 [InstanceEdit:1549606] Rothfels, K, 2011-08-30 [InstanceEdit:1580771] Rothfels, K, 2011-09-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9857433] Rothfels, Karen, 2024-01-04
name	SRC phosphorylates SPRY2 on Y55 and Y227
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:934598] PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1295599] SPRY2 translocates to the plasma membrane [Homo sapiens] [Reaction:1295632] PPA2A dephosphorylates SPRY2 [Homo sapiens]
regulatedBy	[NegativeRegulation:1295631] Negative regulation by 'PP2A(A:C):S112/S121-pSPRY2 [plasma membrane]'
regulationReference	[RegulationReference:9642765] Negative regulation by 'PP2A(A:C):S112/S121-pSPRY2 [plasma membrane]' Regulation of sprouty stability by Mnk1-dependent phosphorylation
releaseDate	2011-09-20
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1591312] R-HSA-1295609.5
summation	[Summation:1295612] Sprouty 2 protein is phosphorylated on tyrosine residue 55. ...
(hasEvent)	[Pathway:1295596] Spry regulation of FGF signaling [Homo sapiens]
(precedingEvent)	[Reaction:1295613] SPRY2 binds GRB2 [Homo sapiens] [Reaction:1295622] SPRY2 binds CBL [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775899] Update Tracker - [Reaction:1295609] SRC phosphorylates SPRY2 on Y55 and Y227 - v78:[modifyText] [_UpdateTracker:9776162] Update Tracker - [Reaction:1295609] SRC phosphorylates SPRY2 on Y55 and Y227 - v77:[modifyText] [_UpdateTracker:9864352] Update Tracker - [Reaction:1295609] SRC phosphorylates SPRY2 on Y55 and Y227 - v88:[add_removeLiteratureReference, modifyText]
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