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Details on Person SPRY2 translocates to the plasma membrane

Class:Id	Reaction:1295599
_displayName	SPRY2 translocates to the plasma membrane
_doRelease	TRUE
_timestamp	2011-09-09 09:07:22
authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:1295600] Rothfels, K, 2011-05-17
input	[Complex:1295593] PPA2A(A:C):SPRY2 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1295620] The C terminus of sprouty is important for modulation of cellular migration and proliferation [LiteratureReference:1295624] Mammalian sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells [LiteratureReference:1295611] Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain [LiteratureReference:1295597] The cysteine-rich sprouty translocation domain targets mitogen-activated protein kinase inhibitory proteins to phosphatidylinositol 4,5-bisphosphate in plasma membranes
modified	[InstanceEdit:1498859] Rothfels, K, 2011-08-18 [InstanceEdit:1549596] Rothfels, K, 2011-08-30 [InstanceEdit:1580770] Rothfels, K, 2011-09-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SPRY2 translocates to the plasma membrane
output	[Complex:934550] PP2A(A:C):SPRY2 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1295632] PPA2A dephosphorylates SPRY2 [Homo sapiens]
releaseDate	2011-09-11
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1591448] R-HSA-1295599.2
summation	[Summation:1295601] SPRY2 translocates to the plasma membrane upon activation of...
(hasEvent)	[Pathway:1295596] Spry regulation of FGF signaling [Homo sapiens]
(precedingEvent)	[Reaction:934559] SPRY2 is phosphorylated by phosphorylated MNK1 [Homo sapiens] [Reaction:1295609] SRC phosphorylates SPRY2 on Y55 and Y227 [Homo sapiens]
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No pathways have been reviewed or authored by SPRY2 translocates to the plasma membrane (1295599)