Query author contributions in Reactome Reactome depends on collaboration between our curation team and outside experts to
assemble and peer-review its pathway modules. The integration of ORCID within Reactome
enables us to meet a key challenge with authoring, curating and reviewing biological
information by incentivizing and crediting the external experts that contribute their
expertise and time to the Reactome curation process. More information is available at
ORCID and Reactome .
If you have an ORCID ID that is not listed on this page, please
forward this information to us and we will update your Reactome pathway records.
Details on Person IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5
Class:Id BlackBoxEvent:1295540 _displayName IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 _doRelease TRUE _timestamp 2017-11-10 08:43:17 authored [InstanceEdit:744679] Ray, KP, 2010-05-17 catalystActivity [CatalystActivity:9025973] protein tyrosine kinase activity of IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B [plasma membrane] compartment [Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane created [InstanceEdit:1295522] Jupe, S, 2011-05-17 edited [InstanceEdit:1264800] Jupe, S, 2011-05-06 input [Complex:9025978] IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] isChimeric FALSE literatureReference [LiteratureReference:1266726] Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain [LiteratureReference:1295521] Characterization of cytokine differential induction of STAT complexes in primary human T and NK cells [LiteratureReference:9025964] Dual mechanism of impairment of interleukin-7 (IL-7) responses in human immunodeficiency virus infection: decreased IL-7 binding and abnormal activation of the JAK/STAT5 pathway modified [InstanceEdit:1295755] Jupe, S, 2011-05-18 [InstanceEdit:1963547] Jupe, S, 2011-11-03 [InstanceEdit:1963554] Jupe, S, 2011-11-03 [InstanceEdit:6785154] Jupe, Steve, 2015-06-25 [InstanceEdit:8983051] Duenas, Corina, 2017-03-22 [InstanceEdit:8983468] Jupe, Steve, 2017-03-23 [InstanceEdit:8983497] Duenas, Corina, 2017-03-24 [InstanceEdit:9020896] Duenas, Corina, 2017-09-11 [InstanceEdit:9020916] Duenas, Corina, 2017-09-11 [InstanceEdit:9021134] Duenas, Corina, 2017-09-14 [InstanceEdit:9021825] Duenas, Corina, 2017-09-21 [InstanceEdit:9022053] Duenas, Corina, 2017-09-21 [InstanceEdit:9022076] Duenas, Corina, 2017-09-21 [InstanceEdit:9022103] Duenas, Corina, 2017-09-21 [InstanceEdit:9022294] Duenas, Corina, 2017-09-22 [InstanceEdit:9023000] Duenas, Corina, 2017-09-26 [InstanceEdit:9025936] Jupe, Steve, 2017-10-16 [InstanceEdit:9025966] Jupe, Steve, 2017-10-16 [InstanceEdit:9025991] Jupe, Steve, 2017-10-16 [InstanceEdit:9028788] Jupe, Steve, 2017-11-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 output [Complex:8982988] IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] precedingEvent
releaseDate 2011-12-06 reviewed [InstanceEdit:1963543] Puck, J, 2011-11-03 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:2016332] R-HSA-1295540.5 summation [Summation:1295526] Signal transducer and activator of transcription 5A or 5B (S... (hasEvent) [Pathway:1266695] Interleukin-7 signaling [Homo sapiens] (normalReaction) [FailedReaction:5602803] Defective JAK3 blocks IL7R-mediated activation of STAT5 [Homo sapiens] (precedingEvent) [Reaction:6785165] p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B [Homo sapiens] [BlackBoxEvent:8983008] IL7 L/R complex binds SOCS2 and CISH [Homo sapiens] [Reaction:9026559] p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B [Homo sapiens] (updatedInstance) [_UpdateTracker:9780218] Update Tracker - [BlackBoxEvent:1295540] IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 - v63:[addLiteratureReference, add_removeCatalystActivity, add_removeInput, modifyText] [_UpdateTracker:9780654] Update Tracker - [BlackBoxEvent:1295540] IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 - v62:[modifyText] [_UpdateTracker:9781273] Update Tracker - [BlackBoxEvent:1295540] IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 - v61:[addCatalystActivity, add_removeInput, add_removeOutput, modifyText] [_UpdateTracker:9784343] Update Tracker - [BlackBoxEvent:1295540] IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 - v54:[addCatalystActivity, add_removeInput, add_removeOutput, modifyText]
[Change default viewing format]
List...
Protein identifiers
ChEBI identifiers
KEGG COMPOUND identifiers
No pathways have been reviewed or authored by IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (1295540)
