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Details on Person Signal transducer and activator of transcription 5A or 5B (S...

Class:Id	Summation:1295526
_displayName	Signal transducer and activator of transcription 5A or 5B (S...
_timestamp	2017-10-20 11:15:24
created	[InstanceEdit:1295522] Jupe, S, 2011-05-17
literatureReference	[LiteratureReference:1266727] Interleukin-7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells [LiteratureReference:1266726] Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain [LiteratureReference:1295521] Characterization of cytokine differential induction of STAT complexes in primary human T and NK cells [LiteratureReference:9025964] Dual mechanism of impairment of interleukin-7 (IL-7) responses in human immunodeficiency virus infection: decreased IL-7 binding and abnormal activation of the JAK/STAT5 pathway [LiteratureReference:9025977] HIV infection perturbs interleukin-7 signaling at the step of STAT5 nuclear relocalization [LiteratureReference:507898] Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells [LiteratureReference:507798] The role of Stat5a and Stat5b in signaling by IL-2 family cytokines
modified	[InstanceEdit:6785154] Jupe, Steve, 2015-06-25 [InstanceEdit:8983492] Duenas, Corina, 2017-03-24 [InstanceEdit:8983499] Duenas, Corina, 2017-03-24 [InstanceEdit:8986224] Duenas, Corina, 2017-04-24 [InstanceEdit:9012675] Duenas, Corina, 2017-07-17 [InstanceEdit:9021133] Duenas, Corina, 2017-09-14 [InstanceEdit:9021824] Duenas, Corina, 2017-09-21 [InstanceEdit:9022053] Duenas, Corina, 2017-09-21 [InstanceEdit:9022714] Duenas, Corina, 2017-09-25 [InstanceEdit:9022918] Duenas, Corina, 2017-09-26 [InstanceEdit:9025966] Jupe, Steve, 2017-10-16 [InstanceEdit:9026554] Jupe, Steve, 2017-10-20
text	Signal transducer and activator of transcription 5A or 5B (STAT5A and/or STAT5B, typically referred to as STAT5) are phosphorylated after Interleukin‑7 (IL7) ligand‑receptor interaction (Foxwell et al. 1995, van der Plas et al. 1996, Yu et al. 1998, Jufrroy et al. 2010, Landires et al. 2011). STAT5 is activated in COS7 cells when co‑transfected with JAK3 (Lin et al. 1996), though this does not demonstrate that JAK3 phosphorylates STAT5 proteins in response to IL7 in vivo (Lin & Leonard, 2000). STAT5 phosphorylation is represented here as a black box event because it is not clear which JAK kinase phosphorylates STAT5 in vivo.
(summation)	[BlackBoxEvent:1295540] IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 [Homo sapiens] [BlackBoxEvent:9025935] STAT5 in IL7:p-Y449-IL7R:JAK1:p-FYN:IL2RG:p-JAK3:MSN,EZR:F-actin:A-microtubule:2x(KIF5B):ATP:2x(KLC1,KLC2,KLC3,KLC4):STAT5A,STAT5B is phosphorylated [Homo sapiens] [BlackBoxEvent:9025941] STAT5 in IL7:p-Y449-IL7R:JAK1:p-FYN:IL2RG:p-JAK3:MSN,EZR:F-actin:A-microtubule:2x(KIF5B):ATP:2x(KLC1,KLC2,KLC3,KLC4):STAT5A,STAT5B is phosphorylated [Homo sapiens]
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