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Details on Person Diagram of PIP3 activates AKT signaling, Constitutive Signaling by Aberrant PI3K in Cancer, Constitutive Signaling by AKT1 E17K in Cancer, and PTEN Loss of Function in Cancer
| Class:Id | PathwayDiagram:1273430 |
|---|---|
| _displayName | Diagram of PIP3 activates AKT signaling, Constitutive Signaling by Aberrant PI3K in Cancer, Constitutive Signaling by AKT1 E17K in Cancer, and PTEN Loss of Function in Cancer |
| _timestamp | 2026-01-26 17:30:40 |
| created | [InstanceEdit:1273429] Jassal, B, 2011-05-11 |
| height | 1506 |
| modified | [InstanceEdit:1277808] Jassal, B, 2011-05-11 [InstanceEdit:1279640] Jassal, B, 2011-05-11 [InstanceEdit:1531247] Orlic-Milacic, Marija, 2011-08-25 [InstanceEdit:1549529] Orlic-Milacic, Marija, 2011-08-29 [InstanceEdit:1549534] Orlic-Milacic, Marija, 2011-08-29 [InstanceEdit:1553000] Matthews, L, 2011-09-04 [InstanceEdit:2218918] Orlic-Milacic, M, 2012-05-01 [InstanceEdit:2218919] Orlic-Milacic, M, 2012-05-01 [InstanceEdit:2219539] Orlic-Milacic, M, 2012-05-01 [InstanceEdit:2243947] Orlic-Milacic, M, 2012-05-09 [InstanceEdit:2245183] Orlic-Milacic, M, 2012-05-09 [InstanceEdit:2316436] Orlic-Milacic, M, 2012-06-09 [InstanceEdit:2317322] Orlic-Milacic, M, 2012-06-09 [InstanceEdit:2317326] Orlic-Milacic, M, 2012-06-09 [InstanceEdit:2317334] Orlic-Milacic, M, 2012-06-09 [InstanceEdit:2317398] Orlic-Milacic, M, 2012-06-11 [InstanceEdit:2318619] Orlic-Milacic, M, 2012-06-14 [InstanceEdit:2318736] Orlic-Milacic, M, 2012-06-15 [InstanceEdit:2321910] Orlic-Milacic, M, 2012-06-18 [InstanceEdit:2325190] Orlic-Milacic, M, 2012-06-18 [InstanceEdit:2326758] Orlic-Milacic, M, 2012-06-18 [InstanceEdit:2326768] Orlic-Milacic, M, 2012-06-18 [InstanceEdit:2327863] Orlic-Milacic, M, 2012-06-21 [InstanceEdit:2394011] Orlic-Milacic, M, 2012-06-28 [InstanceEdit:2395940] Orlic-Milacic, M, 2012-07-06 [InstanceEdit:2399556] Orlic-Milacic, M, 2012-07-10 [InstanceEdit:2399560] Orlic-Milacic, M, 2012-07-10 [InstanceEdit:2399561] Orlic-Milacic, M, 2012-07-11 [InstanceEdit:2399569] Orlic-Milacic, M, 2012-07-11 [InstanceEdit:2399629] Orlic-Milacic, M, 2012-07-11 [InstanceEdit:2399666] Orlic-Milacic, M, 2012-07-12 [InstanceEdit:2399891] Orlic-Milacic, M, 2012-07-12 [InstanceEdit:2399978] Orlic-Milacic, M, 2012-07-13 [InstanceEdit:2399984] Orlic-Milacic, M, 2012-07-13 [InstanceEdit:2400004] Orlic-Milacic, M, 2012-07-13 [InstanceEdit:2400014] Orlic-Milacic, M, 2012-07-13 [InstanceEdit:2404246] Orlic-Milacic, M, 2012-07-16 [InstanceEdit:2404247] Orlic-Milacic, M, 2012-07-16 [InstanceEdit:2409074] Orlic-Milacic, M, 2012-07-17 [InstanceEdit:2413072] Wu, G, 2012-07-17 [InstanceEdit:2460057] Orlic-Milacic, M, 2012-08-30 [InstanceEdit:2632529] Orlic-Milacic, M, 2012-11-21 [InstanceEdit:2632534] Orlic-Milacic, M, 2012-11-21 [InstanceEdit:3039903] Jassal, B, 2013-02-06 [InstanceEdit:3080552] Orlic-Milacic, M, 2013-02-07 [InstanceEdit:3080619] Orlic-Milacic, M, 2013-02-07 [InstanceEdit:3088328] Orlic-Milacic, M, 2013-02-07 [InstanceEdit:3088330] Orlic-Milacic, M, 2013-02-07 [InstanceEdit:3110298] Orlic-Milacic, M, 2013-02-11 [InstanceEdit:3110299] Orlic-Milacic, M, 2013-02-11 [InstanceEdit:3113913] Orlic-Milacic, M, 2013-02-11 [InstanceEdit:3117553] Orlic-Milacic, M, 2013-02-11 [InstanceEdit:3121193] Orlic-Milacic, M, 2013-02-11 [InstanceEdit:3124833] Orlic-Milacic, M, 2013-02-11 [InstanceEdit:3128473] Orlic-Milacic, M, 2013-02-11 [InstanceEdit:3139054] Orlic-Milacic, M, 2013-02-13 [InstanceEdit:5674406] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:5674412] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:5674413] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:5674414] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:5674416] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:5674417] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:6797592] Orlic-Milacic, Marija, 2015-09-14 [InstanceEdit:6797600] Orlic-Milacic, Marija, 2015-09-14 [InstanceEdit:6807086] Orlic-Milacic, Marija, 2015-10-29 [InstanceEdit:6807261] Orlic-Milacic, Marija, 2015-10-30 [InstanceEdit:6807268] Orlic-Milacic, Marija, 2015-10-30 [InstanceEdit:6807274] Orlic-Milacic, Marija, 2015-10-30 [InstanceEdit:6807278] Orlic-Milacic, Marija, 2015-10-30 [InstanceEdit:6807287] Orlic-Milacic, Marija, 2015-10-30 [InstanceEdit:6807292] Orlic-Milacic, Marija, 2015-10-30 [InstanceEdit:6808458] Orlic-Milacic, Marija, 2015-11-04 [InstanceEdit:6808481] Orlic-Milacic, Marija, 2015-11-04 [InstanceEdit:6808483] Orlic-Milacic, Marija, 2015-11-04 [InstanceEdit:6808484] Orlic-Milacic, Marija, 2015-11-04 [InstanceEdit:6810568] Orlic-Milacic, Marija, 2015-11-17 [InstanceEdit:6813607] Orlic-Milacic, Marija, 2015-11-20 [InstanceEdit:8847461] Orlic-Milacic, Marija, 2015-11-30 [InstanceEdit:8847589] Orlic-Milacic, Marija, 2015-12-01 [InstanceEdit:8847590] Orlic-Milacic, Marija, 2015-12-01 [InstanceEdit:8847975] Orlic-Milacic, Marija, 2015-12-03 [InstanceEdit:8847983] Orlic-Milacic, Marija, 2015-12-03 [InstanceEdit:8847984] Orlic-Milacic, Marija, 2015-12-03 [InstanceEdit:8850989] Orlic-Milacic, Marija, 2016-01-04 [InstanceEdit:8850993] Orlic-Milacic, Marija, 2016-01-04 [InstanceEdit:8851012] Orlic-Milacic, Marija, 2016-01-04 [InstanceEdit:8851013] Orlic-Milacic, Marija, 2016-01-04 [InstanceEdit:8855180] Wu, G, 2016-02-02 [InstanceEdit:8857833] Orlic-Milacic, Marija, 2016-02-16 [InstanceEdit:8857941] Orlic-Milacic, Marija, 2016-02-17 [InstanceEdit:8857942] Orlic-Milacic, Marija, 2016-02-17 [InstanceEdit:8858025] Orlic-Milacic, Marija, 2016-02-17 [InstanceEdit:8932658] Orlic-Milacic, Marija, 2016-07-27 [InstanceEdit:8932663] Orlic-Milacic, Marija, 2016-07-27 [InstanceEdit:8932664] Orlic-Milacic, Marija, 2016-07-27 [InstanceEdit:8932727] Orlic-Milacic, Marija, 2016-07-27 [InstanceEdit:8942965] Orlic-Milacic, Marija, 2016-10-21 [InstanceEdit:8942982] Orlic-Milacic, Marija, 2016-10-21 [InstanceEdit:8943808] Orlic-Milacic, Marija, 2016-10-29 [InstanceEdit:8944563] Orlic-Milacic, Marija, 2016-11-04 [InstanceEdit:8948108] Orlic-Milacic, Marija, 2016-11-10 [InstanceEdit:8948109] Orlic-Milacic, Marija, 2016-11-10 [InstanceEdit:8948765] Orlic-Milacic, Marija, 2016-11-16 [InstanceEdit:8982156] Jupe, Steve, 2017-03-16 [InstanceEdit:9021666] Rothfels, Karen, 2017-09-19 [InstanceEdit:9024713] Orlic-Milacic, Marija, 2017-10-06 [InstanceEdit:9603364] Jassal, Bijay, 2018-03-21 [InstanceEdit:9615283] Orlic-Milacic, Marija, 2018-07-31 [InstanceEdit:9615447] Orlic-Milacic, Marija, 2018-08-07 [InstanceEdit:9645116] Wu, G, 2019-05-03 [InstanceEdit:9699047] Matthews, Lisa, 2020-09-09 [InstanceEdit:9732561] Stephan, Ralf, 2021-05-27 [InstanceEdit:9732562] Stephan, Ralf, 2021-05-27 [InstanceEdit:9763924] D'Eustachio, Peter, 2022-02-07 [InstanceEdit:9763925] D'Eustachio, Peter, 2022-02-07 [InstanceEdit:9763928] D'Eustachio, Peter, 2022-02-07 [InstanceEdit:9764572] D'Eustachio, Peter, 2022-02-11 [InstanceEdit:9767866] Shamovsky, Veronica, 2022-03-01 [InstanceEdit:9768042] Orlic-Milacic, Marija, 2022-03-03 [InstanceEdit:9796645] Shamovsky, Veronica, 2022-08-10 [InstanceEdit:9830722] Orlic-Milacic, Marija, 2023-03-13 [InstanceEdit:9833348] Orlic-Milacic, Marija, 2023-04-20 [InstanceEdit:9865757] Orlic-Milacic, Marija, 2024-03-18 [InstanceEdit:9980238] Orlic-Milacic, Marija, 2026-01-26 |
| representedPathway | [Pathway:1257604] PIP3 activates AKT signaling [Homo sapiens] [Pathway:2219530] Constitutive Signaling by Aberrant PI3K in Cancer [Homo sapiens] [Pathway:5674400] Constitutive Signaling by AKT1 E17K in Cancer [Homo sapiens] [Pathway:5674404] PTEN Loss of Function in Cancer [Homo sapiens] |
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textPosition="701 749" bgColor="184 154 230" fgColor="161 1 2" lineColor="255 0 0" isForDrug="true" isForDisease="true" hideComponents="true"> <Properties> <displayName>PI3K Inhibitors:PI3K</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1977" reactomeId="2682356" position="761 379" bounds="741 368 40 22" textPosition="741 368"> <Properties> <displayName>SGK1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="1978" reactomeId="29370" position="968 434" bounds="950 420 36 28" textPosition="952 423"> <Properties> <displayName>ADP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="1979" reactomeId="6795313" position="1027 379" bounds="974 365 106 28" textPosition="983 368"> <Properties> <displayName>p-S422-SGK1</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.1509433962264151" relativeY="0.0" label="P" trackId="0" reactomeId="6795307" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="1989" reactomeId="113592" position="1126 421" bounds="1106 406 40 30" textPosition="1111 410" /> <org.gk.render.RenderableChemical id="1990" reactomeId="29370" position="1276 264" bounds="1256 249 41 30" textPosition="1260 253" /> <org.gk.render.RenderableProtein id="1991" reactomeId="6795449" position="1197 221" bounds="1126 208 142 26" textPosition="1136 210"> <Properties> <displayName>p-T256,S422-SGK1</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.0" relativeY="0.0" label="P" trackId="0" reactomeId="6795307" /> <org.gk.render.RenderableFeature relativeX="0.0" relativeY="0.6923076923076923" label="P" trackId="0" reactomeId="6795466" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="1998" reactomeId="113592" position="806 420" bounds="788 409 36 23" textPosition="791 409"> <Properties> <displayName>ATP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="2067" reactomeId="9980228" position="828 150" bounds="787 139 82 23" textPosition="787 140" bgColor="204 255 255" hideComponents="true" /> </Nodes> <Edges> <org.gk.render.RenderableReaction id="360" reactomeId="198640" points="651 177, 676 178, 729 176" position="676 178" lineWidth="1.0"> <Inputs> <Input id="574" points="516 125" /> <Input id="576" points="640 194" /> </Inputs> <Outputs> <Output id="534" points="778 128" /> <Output id="535" points="748 191" /> </Outputs> <Catalysts> <Catalyst id="2067" points="823 165, 795 229, 682 218" /> </Catalysts> <Inhibitors> <Inhibitor id="347" points="682 134" /> </Inhibitors> <Properties> <displayName>TORC2 (mTOR) phosphorylates AKT at S473</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="362" reactomeId="198270" points="1649 176, 1649 217, 1650 257" position="1649 217" lineWidth="1.0"> <Inputs> <Input id="548" points="1629 172" /> <Input id="545" points="1696 132" /> </Inputs> <Outputs> <Output id="537" points="1541 125" /> <Output id="312" points="1649 593" /> <Output id="551" points="1621 274" /> </Outputs> <Catalysts> <Catalyst id="545" points="1703 132, 1672 200" /> </Catalysts> <Inhibitors> <Inhibitor id="1963" points="1688 228, 1666 219" /> </Inhibitors> <Properties> <displayName>PDPK1 phosphorylates AKT at T308</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="363" reactomeId="198298" points="1640 635, 1400 1033, 1360 1033" position="1400 1033" lineWidth="1.0"> <Inputs> <Input id="312" /> </Inputs> <Outputs> <Output id="307" /> </Outputs> <Properties> <displayName>AKT translocates to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="364" reactomeId="198611" points="2168 579, 2169 729, 2169 817" position="2169 729" lineWidth="1.0"> <Inputs> <Input id="320" points="2056 543" /> <Input id="336" points="2258 531" /> </Inputs> <Outputs> <Output id="332" points="2061 805" /> <Output id="1163" points="2271 856" /> </Outputs> <Catalysts> <Catalyst id="312" points="1702 624" /> </Catalysts> <Properties> <displayName>AKT phosphorylates IKKalpha</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="365" reactomeId="198609" points="2205 528, 2206 707, 2207 793" position="2206 707" lineWidth="1.0"> <Inputs> <Input id="786" points="2260 482" /> <Input id="320" stoichiometry="2" points="2056 536" /> </Inputs> <Outputs> <Output id="1084" points="2284 811" /> <Output id="332" stoichiometry="2" points="2061 802" /> </Outputs> <Catalysts> <Catalyst id="312" points="1702 621" /> </Catalysts> <Properties> <displayName>AKT phosphorylates TSC2, inhibiting it</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="366" reactomeId="198621" points="2149 622, 2149 754, 2149 843" position="2149 754" lineWidth="1.0"> <Inputs> <Input id="1962" points="2277 579" /> <Input id="320" points="2056 552" /> </Inputs> <Outputs> <Output id="332" points="2061 811" /> <Output id="1242" points="2230 894" /> </Outputs> <Catalysts> <Catalyst id="312" points="1702 627" /> </Catalysts> <Properties> <displayName>AKT phosphorylates caspase-9</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="367" reactomeId="198371" points="1974 580, 1974 652, 1972 856" position="1974 652" lineWidth="1.0"> <Inputs> <Input id="320" points="2011 551" /> <Input id="324" points="1823 545" /> </Inputs> <Outputs> <Output id="335" points="1893 957" /> <Output id="332" points="2019 822" /> </Outputs> <Catalysts> <Catalyst id="312" points="1702 619" /> </Catalysts> <Properties> <displayName>AKT phosphorylates GSK3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="368" reactomeId="198613" points="1895 478, 1894 570, 1893 754" position="1894 570" lineWidth="1.0"> <Inputs> <Input id="1698" points="1845 441" /> <Input id="320" points="2011 529" /> </Inputs> <Outputs> <Output id="332" points="2015 797" /> <Output id="321" points="1770 770" /> </Outputs> <Catalysts> <Catalyst id="312" points="1702 605" /> </Catalysts> <Properties> <displayName>AKT phosphorylates p21Cip1 and p27Kip1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="369" reactomeId="198599" points="2124 650, 2124 768, 2124 873" position="2124 768" lineWidth="1.0"> <Inputs> <Input id="330" points="2258 613" /> <Input id="320" stoichiometry="2" points="2044 556" /> </Inputs> <Outputs> <Output id="323" points="2176 966" /> <Output id="332" stoichiometry="2" points="2056 822" /> </Outputs> <Catalysts> <Catalyst id="312" points="1695 635" /> </Catalysts> <Properties> <displayName>AKT phosphorylates MDM2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="370" reactomeId="200143" points="1913 505, 1914 589, 1914 792" position="1914 589" lineWidth="1.0"> <Inputs> <Input id="334" points="1913 416" /> <Input id="320" stoichiometry="2" points="2011 532" /> </Inputs> <Outputs> <Output id="1082" points="1792 817" /> <Output id="332" stoichiometry="2" points="2015 802" /> </Outputs> <Catalysts> <Catalyst id="312" points="1702 609" /> </Catalysts> <Properties> <displayName>AKT phosphorylates AKT1S1 (PRAS40)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="371" reactomeId="198347" points="1957 553, 1956 628, 1951 843" position="1956 628" lineWidth="1.0"> <Inputs> <Input id="320" points="2011 541" /> <Input id="326" points="1832 510" /> </Inputs> <Outputs> <Output id="332" points="2015 812" /> <Output id="1083" points="1800 930" /> </Outputs> <Catalysts> <Catalyst id="312" points="1702 616" /> </Catalysts> <Properties> <displayName>AKT phosphorylates BAD</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="372" reactomeId="199298" points="1225 882, 1227 986, 1234 1096" position="1227 986" lineWidth="1.0"> <Inputs> <Input id="342" points="1086 889" /> <Input id="343" points="1243 846" /> </Inputs> <Outputs> <Output id="339" points="1076 1229" /> <Output id="1001" points="1255 1107" /> </Outputs> <Catalysts> <Catalyst id="307" points="1285 1015" /> </Catalysts> <Properties> <displayName>AKT phosphorylates CREB1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="373" reactomeId="199839" points="1205 936, 1205 1009, 1209 1160" position="1205 1009" lineWidth="1.0"> <Inputs> <Input id="342" stoichiometry="2" points="1086 899" /> <Input id="340" points="1266 885" /> </Inputs> <Outputs> <Output id="339" stoichiometry="2" points="1084 1229" /> <Output id="1081" points="1244 1172" /> </Outputs> <Catalysts> <Catalyst id="307" points="1256 1022" /> </Catalysts> <Properties> <displayName>AKT can phosphorylate RSK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="374" reactomeId="199299" points="1185 953, 1187 1031, 1190 1192" position="1187 1031" lineWidth="1.0"> <Inputs> <Input id="342" stoichiometry="3" points="1086 903" /> <Input id="346" points="1256 934" /> </Inputs> <Outputs> <Output id="1882" points="1244 1229" /> <Output id="339" stoichiometry="3" points="1090 1234" /> </Outputs> <Catalysts> <Catalyst id="307" points="1256 1032" /> </Catalysts> <Properties> <displayName>AKT phosphorylates FOXO transcription factors</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="375" reactomeId="199863" points="1165 973, 1168 1063, 1172 1245" position="1168 1063" lineWidth="1.0"> <Inputs> <Input id="342" points="1073 908" /> <Input id="337" points="1267 969" /> </Inputs> <Outputs> <Output id="339" points="1090 1245" /> <Output id="1080" points="1193 1310" /> </Outputs> <Catalysts> <Catalyst id="307" points="1256 1043" /> </Catalysts> <Properties> <displayName>AKT can phosphorylate NR4A1 (NUR77)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="376" reactomeId="199443" points="610 70, 647 70, 669 92" position="647 70" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="574" points="516 103" /> <Input id="784" points="599 91" /> </Inputs> <Outputs> <Output id="347" /> </Outputs> <Properties> <displayName>THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="377" reactomeId="199456" points="497 357, 498 388, 497 425" position="498 388" lineWidth="1.0"> <Inputs> <Input id="313" points="347 279" /> <Input id="355" points="526 339" /> </Inputs> <Outputs> <Output id="353" points="332 586" /> <Output id="357" points="510 437" /> </Outputs> <Catalysts> <Catalyst id="1796" points="534 386" /> </Catalysts> <Properties> <displayName>PTEN dephosphorylates PIP3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="378" reactomeId="199425" points="1607 563, 1563 565, 1519 567" position="1563 565" lineWidth="1.0"> <Inputs> <Input id="312" points="1636 593" /> <Input id="555" points="1615 539" /> </Inputs> <Outputs> <Output id="556" points="1503 593" /> <Output id="359" points="1501 540" /> </Outputs> <Catalysts> <Catalyst id="352" points="1563 522" /> </Catalysts> <Properties> <displayName>PHLPP dephosphorylates S473 in AKT</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="419" reactomeId="2219524" points="261 234, 302 58, 1124 29, 1202 96" position="1124 29" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="420" points="387 199" /> <Input id="353" points="301 586, 234 514" /> </Inputs> <Outputs> <Output id="421" /> </Outputs> <Properties> <displayName>PDPK1 binds PIP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="432" reactomeId="2219536" points="910 242, 908 181, 908 135" position="908 181" lineWidth="2.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="433" points="938 260" /> <Input id="353" points="342 586" /> </Inputs> <Outputs> <Output id="434" /> </Outputs> <Properties> <displayName>AKT1 E17K mutant binds PIP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="443" reactomeId="2243938" points="998 151, 1019 151, 1042 151" position="1019 151" lineWidth="2.0" isForDisease="true" lineColor="255 0 0" reactionType="Transition"> <Inputs> <Input id="434" points="952 135" /> <Input id="540" points="980 165" /> </Inputs> <Outputs> <Output id="471" points="1069 134" /> <Output id="541" points="1058 166" /> </Outputs> <Catalysts> <Catalyst id="2067" points="872 150" /> </Catalysts> <Properties> <displayName>AKT1 E17K mutant is phosphorylated by TORC2 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="477" reactomeId="2243937" points="1158 159, 1215 159, 1271 136" position="1215 159" lineWidth="2.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="471" points="1119 134" /> <Input id="421" points="1202 124" /> </Inputs> <Outputs> <Output id="478" /> </Outputs> <Properties> <displayName>PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="486" reactomeId="2243942" points="1391 164, 1390 211, 1390 255" position="1390 211" lineWidth="2.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="487" points="1426 160" /> <Input id="478" points="1359 144" /> </Inputs> <Outputs> <Output id="488" points="1347 298" /> <Output id="421" points="1228 124" /> <Output id="489" points="1436 301" /> </Outputs> <Catalysts> <Catalyst id="478" points="1334 144, 1357 211" /> </Catalysts> <Properties> <displayName>PDPK1 phosphorylates AKT1 E17K mutant</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="497" reactomeId="2316434" points="384 444, 384 410, 385 375" position="384 410" lineWidth="1.0"> <Inputs> <Input id="498" points="399 464" /> <Input id="353" points="322 586" /> </Inputs> <Outputs> <Output id="499" points="404 357" /> <Output id="313" points="327 279" /> </Outputs> <Catalysts> <Catalyst id="500" points="354 411" /> </Catalysts> <Activators> <Activator id="1869" points="496 571, 452 408" /> </Activators> <Properties> <displayName>PI3K phosphorylates PIP2 to PIP3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="536" reactomeId="2316429" points="357 182, 379 146, 414 23, 1403 4, 1519 97" position="379 146" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="420" points="387 187" /> <Input id="313" points="326 241" /> </Inputs> <Outputs> <Output id="537" /> </Outputs> <Properties> <displayName>PIP3 recruits PDPK1 to the membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="544" reactomeId="2317314" points="1512 51, 1584 49, 1687 103" position="1584 49" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="537" points="1529 97" /> <Input id="534" points="800 98, 843 54" /> </Inputs> <Outputs> <Output id="545" /> </Outputs> <Properties> <displayName>AKT binds PDPK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="582" reactomeId="2317332" points="484 196, 480 160, 480 129" position="480 160" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="313" points="358 245" /> <Input id="392" points="526 223" /> </Inputs> <Outputs> <Output id="574" /> </Outputs> <Properties> <displayName>PIP3 recruits AKT to the membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="774" reactomeId="2400010" points="1367 450, 1367 484, 1368 512" position="1367 484" lineWidth="2.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="775" points="1421 415" /> <Input id="777" points="1326 415" /> </Inputs> <Outputs> <Output id="781" /> </Outputs> <Properties> <displayName>AKT inhibitors block AKT membrane recruitment</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="778" points="1001 288, 1267 373" position="1134 330" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="433" /> </Inputs> <Outputs> <Output id="777" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="779" points="564 243, 1236 373" position="900 308" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="392" /> </Inputs> <Outputs> <Output id="777" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="793" points="354 425, 648 550" position="501 487" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="500" /> </Inputs> <Outputs> <Output id="792" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableInteraction id="824" interactionType="Activate" points="178 120, 200 120, 306 388" position="200 120" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="815" /> </Inputs> <Outputs> <Output id="500" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="825" interactionType="Activate" points="177 176, 197 176, 304 388" position="197 176" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="816" /> </Inputs> <Outputs> <Output id="500" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="826" interactionType="Activate" points="175 232, 199 232, 302 388" position="199 232" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="817" /> </Inputs> <Outputs> <Output id="500" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="827" interactionType="Activate" points="170 294, 191 296, 294 388" position="191 296" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="818" /> </Inputs> <Outputs> <Output id="500" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="828" interactionType="Activate" points="162 369, 275 402" position="218 385" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="819" /> </Inputs> <Outputs> <Output id="500" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="829" interactionType="Activate" points="168 402, 275 409" position="221 405" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="822" /> </Inputs> <Outputs> <Output id="500" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="830" interactionType="Activate" points="169 444, 275 419" position="222 431" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="820" /> </Inputs> <Outputs> <Output id="500" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="831" interactionType="Activate" points="168 527, 181 527, 292 437" position="181 527" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="821" /> </Inputs> <Outputs> <Output id="500" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="832" interactionType="Activate" points="170 597, 185 597, 301 437" position="185 597" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="823" /> </Inputs> <Outputs> <Output id="500" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1243" interactionType="Activate" points="1780 959, 1780 1025" position="1780 992" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="1083" /> </Inputs> <Outputs> <Output id="788" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="1526" reactomeId="1676082" points="464 1348, 462 1286, 463 1169" position="462 1286" lineWidth="1.0"> <Inputs> <Input id="1533" points="413 1400" /> <Input id="1527" points="343 1398" /> </Inputs> <Outputs> <Output id="353" points="320 624" /> <Output id="1534" points="535 1093" /> </Outputs> <Catalysts> <Catalyst id="1530" points="529 1286" /> </Catalysts> <Properties> <displayName>PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1531" reactomeId="1675776" points="512 1334, 511 1258, 512 1112" position="511 1258" lineWidth="1.0"> <Inputs> <Input id="1532" points="1459 1445, 631 1415" /> <Input id="1533" points="418 1400" /> </Inputs> <Outputs> <Output id="353" points="322 624" /> <Output id="1534" points="534 1093" /> </Outputs> <Catalysts> <Catalyst id="1535" points="571 1226" /> </Catalysts> <Properties> <displayName>PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1545" reactomeId="6811504" points="1826 1211, 1827 1258, 1827 1323" position="1827 1258" lineWidth="1.0"> <Inputs> <Input id="1546" stoichiometry="2" points="1866 1188" /> <Input id="1547" points="1798 1193" /> </Inputs> <Outputs> <Output id="1549" points="1810 1378" /> <Output id="1553" stoichiometry="2" points="1870 1376" /> </Outputs> <Catalysts> <Catalyst id="1551" points="1887 1255" /> </Catalysts> <Inhibitors> <Inhibitor id="1532" points="1493 1430, 1576 1258" /> </Inhibitors> <Properties> <displayName>AKT1 dephosphorylation by PP2A-B56-beta,gamma</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="1548" points="1710 1152, 1643 1131, 1648 635" position="1643 1131" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1547" /> </Inputs> <Outputs> <Output id="312" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1550" points="1802 1407, 1769 1492, 697 1488, 627 823, 614 350, 548 257" position="662 1155" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1549" /> </Inputs> <Outputs> <Output id="392" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="1556" reactomeId="6811472" points="2058 1272, 2057 1306, 2057 1358" position="2057 1306" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1557" points="2058 1210" /> <Input id="1551" points="1993 1261" /> <Input id="1558" points="2082 1263" /> </Inputs> <Outputs> <Output id="1559" /> </Outputs> <Properties> <displayName>IER3 recruits MAPKs to PP2A-B56-beta,gamma</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1560" reactomeId="6811454" points="2167 1331, 2168 1271, 2167 1219" position="2168 1271" lineWidth="1.0"> <Inputs> <Input id="1561" points="2192 1343" /> <Input id="1559" points="2102 1358" /> </Inputs> <Outputs> <Output id="1562" points="2203 1111" /> <Output id="1563" points="2130 1150" /> <Output id="1564" points="2204 1197" /> <Output id="1557" points="2111 1210" /> <Output id="1558" points="2121 1243" /> </Outputs> <Catalysts> <Catalyst id="1559" points="2071 1358, 2136 1271" /> </Catalysts> <Properties> <displayName>MAPKs phosphorylate PP2A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1572" interactionType="Activate" points="1986 1088, 2048 1169" position="2017 1128" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="1571" /> </Inputs> <Outputs> <Output id="1557" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="1691" reactomeId="8857925" points="1641 1338, 1673 1338, 1702 1338" position="1673 1338" lineWidth="1.0"> <Inputs> <Input id="1692" points="1622 1348" /> <Input id="1693" points="1623 1328" /> </Inputs> <Outputs> <Output id="1694" points="1718 1348" /> <Output id="1695" points="1720 1323" /> </Outputs> <Catalysts> <Catalyst id="1696" points="1673 1394" /> </Catalysts> <Activators> <Activator id="1532" points="1516 1436, 1629 1392" /> </Activators> <Properties> <displayName>Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1700" interactionType="Activate" points="1828 399, 1829 350" position="1828 374" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="1698" /> </Inputs> <Outputs> <Output id="841" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1718" interactionType="Activate" points="172 663, 186 663, 304 437" position="186 663" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="1717" /> </Inputs> <Outputs> <Output id="500" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1744" interactionType="Activate" points="170 727, 189 727, 306 437" position="189 727" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="1743" /> </Inputs> <Outputs> <Output id="500" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1765" interactionType="Activate" points="2272 454, 2271 423" position="2271 438" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="786" /> </Inputs> <Outputs> <Output id="1763" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1766" interactionType="Activate" points="1948 397, 2200 397" position="2074 397" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="334" /> </Inputs> <Outputs> <Output id="1763" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1770" interactionType="Activate" points="2254 980, 2300 979" position="2277 979" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="323" /> </Inputs> <Outputs> <Output id="1769" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1862" interactionType="Activate" points="1281 718, 590 400" position="935 559" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="1861" /> </Inputs> <Outputs> <Output id="1796" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="1863" reactomeId="8948757" points="1935 534, 1936 607, 1934 824" position="1936 607" lineWidth="1.0"> <Inputs> <Input id="1865" points="1834 479" /> <Input id="320" points="2011 537" /> </Inputs> <Outputs> <Output id="1867" points="1786 877" /> <Output id="332" points="2015 807" /> </Outputs> <Catalysts> <Catalyst id="312" points="1702 612" /> </Catalysts> <Properties> <displayName>AKT phosphorylates MKRN1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1868" interactionType="Activate" points="1712 877, 1415 773" position="1563 825" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="1867" /> </Inputs> <Outputs> <Output id="1861" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1872" interactionType="Activate" points="169 787, 202 784, 308 437" position="202 784" lineWidth="2.0"> <Inputs> <Input id="1870" /> </Inputs> <Outputs> <Output id="500" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1881" interactionType="Activate" points="1710 1173, 1622 1177" position="1666 1175" lineWidth="2.0"> <Inputs> <Input id="1547" /> </Inputs> <Outputs> <Output id="1879" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="1895" reactomeId="114542" points="342 1155, 352 1120, 317 1056" position="352 1120" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1896" points="366 1179" /> <Input id="1897" points="319 1220" /> </Inputs> <Outputs> <Output id="1898" /> </Outputs> <Properties> <displayName>RAC1,RAC2,RHOG activate PI3K</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="1899" points="289 986, 220 801, 309 437" position="220 801" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1898" /> </Inputs> <Outputs> <Output id="500" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="1954" reactomeId="9732513" points="416 702, 416 702, 325 762" position="416 702" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="500" points="320 437" /> <Input id="1955" points="466 694" /> </Inputs> <Outputs> <Output id="1957" /> </Outputs> <Properties> <displayName>PI3K inhibitors bind to Activator:PI3K</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1970" interactionType="Activate" points="1779 240, 1752 240" position="1765 240" lineWidth="2.0"> <Inputs> <Input id="1968" /> </Inputs> <Outputs> <Output id="1963" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="1971" reactomeId="2400009" points="759 662, 760 692, 760 743" position="760 692" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="792" points="722 605" /> <Input id="1972" points="834 606" /> </Inputs> <Outputs> <Output id="1974" /> </Outputs> <Properties> <displayName>PI3K inhibitors block PI3K catalytic activity</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndEntitySetLink id="1973" points="793 598, 553 671" position="673 634" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="1972" /> </Inputs> <Outputs> <Output id="1955" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="1975" reactomeId="6795290" points="838 382, 878 384, 919 378" position="878 384" lineWidth="1.0"> <Inputs> <Input id="1977" points="784 379" /> <Input id="1998" points="815 406" /> </Inputs> <Outputs> <Output id="1978" points="955 417" /> <Output id="1979" points="971 378" /> </Outputs> <Catalysts> <Catalyst id="2067" points="830 165" /> </Catalysts> <Properties> <displayName>TORC2 complex phosphorylates SGK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1988" reactomeId="6795473" points="1100 337, 1172 356, 1212 271" position="1172 356" lineWidth="1.0"> <Inputs> <Input id="1989" points="1121 403" /> <Input id="1979" points="1051 362" /> </Inputs> <Outputs> <Output id="1990" points="1253 266" /> <Output id="1991" points="1200 237" /> </Outputs> <Catalysts> <Catalyst id="537" points="1531 125, 1496 358" /> </Catalysts> <Properties> <displayName>PDPK1 phosphorylates SGK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2066" reactomeId="9980233" points="604 286, 684 247, 818 253, 826 165" position="684 247" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="306" points="666 298" /> <Input id="313" points="358 263" /> </Inputs> <Outputs> <Output id="2067" /> </Outputs> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process> |
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No pathways have been reviewed or authored by Diagram of PIP3 activates AKT signaling, Constitutive Signaling by Aberrant PI3K in Cancer, Constitutive Signaling by AKT1 E17K in Cancer, and PTEN Loss of Function in Cancer (1273430)
