Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person FRS2 has 8 canonical MAPK phosphorylation sites which are ph...
| Class:Id | Summation:1268241 |
|---|---|
| _displayName | FRS2 has 8 canonical MAPK phosphorylation sites which are ph... |
| _timestamp | 2014-12-03 20:41:58 |
| created | [InstanceEdit:1268242] Rothfels, K, 2011-05-09 |
| modified | [InstanceEdit:1433597] Rothfels, K, 2011-07-11 [InstanceEdit:5654385] Rothfels, Karen, 2014-12-03 |
| text | FRS2 has 8 canonical MAPK phosphorylation sites which are phosphorylated by activated ERK1/2 after FGF stimulation. Phosphorylation of these 8 threonine residues counteracts the activating effect of tyrosine phosphorylation of FRS2, although the exact mechanism for this negative regulation is not known. Expression of a version of FRS2 in which the 8 threonine residues are mutated to valine results in enhanced tyrosine phosphorylation of FRS2, enhanced GRB2-SOS1 recruitment and a more sustained MAPK response. The 8 threonine residues are not conserved in FRS3; as a result, signaling through FRS3 complexes do not appear to be subject to this downregulation. |
| (summation) | [Reaction:5654560] Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2 [Homo sapiens] [Reaction:5654562] Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 [Homo sapiens] [Reaction:5654565] Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2 [Homo sapiens] [Reaction:5654566] Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by FRS2 has 8 canonical MAPK phosphorylation sites which are ph... (1268241)
