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Details on Person TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space

Class:Id	Reaction:1268022
_displayName	TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space
_doRelease	TRUE
_timestamp	2014-02-06 21:34:57
authored	[InstanceEdit:1258402] May, B, 2011-05-03
catalystActivity	[CatalystActivity:1268023] transmembrane protein transporter activity of TOMM40 Complex [mitochondrial outer membrane]
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane [Compartment:17927] mitochondrial intermembrane space
created	[InstanceEdit:1268021] May, B, 2011-05-09
edited	[InstanceEdit:1258402] May, B, 2011-05-03
inferredFrom	[Reaction:1252255] TOM40:TOM70 complex translocates proteins from the cytosol to the mitochondrial intermembrane space [Saccharomyces cerevisiae]
input	[CandidateSet:1268006] Cargo of TOMM40 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1267918] Dissection of the mitochondrial import and assembly pathway for human Tom40 [LiteratureReference:1252288] Roles of Tom70 in import of presequence-containing mitochondrial proteins [LiteratureReference:1307738] Multiple pathways for mitochondrial protein traffic [LiteratureReference:1307739] Multiple pathways for sorting mitochondrial precursor proteins
modified	[InstanceEdit:1307804] May, B, 2011-05-29 [InstanceEdit:1480933] May, B, 2011-08-11 [InstanceEdit:1977303] May, B, 2011-11-08 [InstanceEdit:2010553] May, B, 2011-11-22 [InstanceEdit:2108992] May, B, 2012-02-12 [InstanceEdit:2127546] May, B, 2012-02-15 [InstanceEdit:2143820] May, B, 2012-02-26 [InstanceEdit:5257491] May, B, 2014-02-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space
output	[CandidateSet:1268010] Cargo of TOMM40 [mitochondrial intermembrane space] [Homo sapiens]
releaseDate	2012-03-13
reviewed	[InstanceEdit:1914221] D'Eustachio, P, 2011-11-01 [InstanceEdit:2108993] Endo, T, 2012-02-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2158105] R-HSA-1268022.2
summation	[Summation:1267887] As inferred from the yeast TOM40:TOM70 complex, the human TO...
(hasEvent)	[Pathway:1268020] Mitochondrial protein import [Homo sapiens]
(precedingEvent)	[Reaction:1268025] SAM50 complex inserts proteins into mitochondrial outer membrane [Homo sapiens] [Reaction:1299480] Precursor proteins enter TIMM23 PAM [Homo sapiens] [Reaction:1299481] TIMM9:TIMM10 binds hydrophobic proteins [Homo sapiens] [Reaction:1299484] TIMM8:TIMM13 chaperones hydrophobic proteins [Homo sapiens] [Reaction:1299487] Precursor proteins enter TIMM23 SORT [Homo sapiens] [Reaction:1307802] MIA40:ERV1 (CHCHD4:GFER) oxidizes cysteine residues to cystine disulfide bonds [Homo sapiens] [Reaction:1307803] TIMM22 inserts proteins into inner membrane [Homo sapiens]
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