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| Class:Id | Summation:1267877 |
|---|---|
| _displayName | TRAFs are E3 ubiquitin ligases that catalyse Lys63-polyubqui... |
| _timestamp | 2011-05-23 20:20:30 |
| created | [InstanceEdit:1267878] Shamovsky, V, 2011-05-09 |
| literatureReference | [LiteratureReference:1250152] Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response [LiteratureReference:936463] DUBA: a deubiquitinase that regulates type I interferon production |
| modified | [InstanceEdit:1273407] Shamovsky, V, 2011-05-11 [InstanceEdit:1300654] Shamovsky, V, 2011-05-23 |
| text | TRAFs are E3 ubiquitin ligases that catalyse Lys63-polyubquitination of associated target proteins and possibly on themselves. Virus- triggered Lys63-polyubiquitination of TRAF3/ or TRAF6 was shown to be essential for induction of IFN production [Mao AP et al 2010]. Furthermore, Kayagaki et al. demonstrated that deubiquitinating enzyme A (DUBA) specifically removed Lys63-linked polyubiquitin chains from TRAF3, resulting in its dissociation from the IFN signaling complex [Kayagaki N et al 2007]. |
| (summation) | [BlackBoxEvent:1227893] TRAF3/or TRAF6 ubiquitination within dsRNA:MDA5:IPS1:TRAF3/TRAF6 complex [Gallus gallus] |
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