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Details on Person Interleukin-7 receptor (IL7R) has a small juxta-membrane reg...

Class:IdSummation:1264812
_displayNameInterleukin-7 receptor (IL7R) has a small juxta-membrane reg...
_timestamp2017-11-10 08:43:24
created[InstanceEdit:1264814] Jupe, S, 2011-05-06
literatureReference[LiteratureReference:1264816] Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family
[LiteratureReference:1264834] The conserved box 1 motif of cytokine receptors is required for association with JAK kinases
[LiteratureReference:1264807] Distinct regions of the interleukin-7 receptor regulate different Bcl2 family members
[LiteratureReference:1264806] Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7R alpha mutant mice
[LiteratureReference:1264827] Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors
[LiteratureReference:1264825] Cell biology of IL-7, a key lymphotrophin
[LiteratureReference:1264820] The role of Jak3 in lymphoid development, activation, and signaling
modified[InstanceEdit:1266679] Jupe, S, 2011-05-06
[InstanceEdit:1295755] Jupe, S, 2011-05-18
[InstanceEdit:1430758] Jupe, S, 2011-07-07
[InstanceEdit:6785154] Jupe, Steve, 2015-06-25
[InstanceEdit:8983054] Duenas, Corina, 2017-03-22
[InstanceEdit:8986223] Duenas, Corina, 2017-04-24
[InstanceEdit:9012845] Duenas, Corina, 2017-07-20
[InstanceEdit:9025936] Jupe, Steve, 2017-10-16
[InstanceEdit:9028788] Jupe, Steve, 2017-11-10
textInterleukin-7 receptor (IL7R) has a small juxta-membrane region known as the Box1 motif, which is conserved throughout the type 1 cytokine receptor family (Murakami et al. 1991) and believed to be the site of JAK1 binding (Tanner et al. 1995). Deletion of the Box1 region of IL7R eliminates JAK1 phosphorylation (Jiang et al. 2004). Studies using mutant Interleukin-4/Interleukin-7 chimeric receptors found that loss of Box1 resulted in rapid cell death, while Y449F mutation causes cell cycle arrest that precedes cell death (Jiang et al. 2004). Mice expressing a knock-in mutation (IL7R Y449F) displayed defective homeostatic proliferation of naive CD4 and CD8 T-cells (Osbourne et al. 2007). The Y449 site is thus of particular interest because two critical Interleukin-7 signaling pathways, the JAK/STAT pathway and the phosphatidylinositol 3-kinase (PI3K)/AKT pathway may originate from this site (Pallard et al. 1999).
(summation)[Reaction:1264832] JAK1 binds IL7R [Homo sapiens]
[Reaction:1295768] Jak1 binds Il7r [Mus musculus]
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