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Details on Person TIM23 PAM complex translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix

Class:Id	Reaction:1252253
_displayName	TIM23 PAM complex translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix
_doRelease	TRUE
_timestamp	2014-02-06 21:34:17
authored	[InstanceEdit:1252340] May, B, 2011-04-27
catalystActivity	[CatalystActivity:1252250] transmembrane protein transporter activity of TIM23 PAM:Cargo [mitochondrial inner membrane]
catalystActivityReference	[CatalystActivityReference:9643623] protein transmembrane transporter activity of TIM23 PAM:Cargo [mitochondrial inner membrane] Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:1252251] May, B, 2011-04-27
edited	[InstanceEdit:1252340] May, B, 2011-04-27
input	[Complex:1268008] TIM23 PAM:Cargo [mitochondrial inner membrane] [Saccharomyces cerevisiae] [SimpleEntity:113593] ATP [mitochondrial matrix]
isChimeric	FALSE
literatureReference	[LiteratureReference:1252376] Tim50, a novel component of the TIM23 preprotein translocase of mitochondria [LiteratureReference:1254311] Role of the mitochondrial Hsp70s, Ssc1 and Ssq1, in the maturation of Yfh1 [LiteratureReference:1252342] Mitochondrial protein import motor: differential role of Tim44 in the recruitment of Pam17 and J-complex to the presequence translocase [LiteratureReference:1252351] Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria [LiteratureReference:1258382] Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17 [LiteratureReference:1258397] Distinct forms of mitochondrial TOM-TIM supercomplexes define signal-dependent states of preprotein sorting [LiteratureReference:1258386] Characterization of Mmp37p, a Saccharomyces cerevisiae mitochondrial matrix protein with a role in mitochondrial protein import [LiteratureReference:1252368] Modular structure of the TIM23 preprotein translocase of mitochondria [LiteratureReference:1252293] A cooperative action of the ATP-dependent import motor complex and the inner membrane potential drives mitochondrial preprotein import [LiteratureReference:1254313] Pam16 has an essential role in the mitochondrial protein import motor [LiteratureReference:1254317] Pam17 is required for architecture and translocation activity of the mitochondrial protein import motor [LiteratureReference:1254323] A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria [LiteratureReference:1254309] Role of Pam16's degenerate J domain in protein import across the mitochondrial inner membrane [LiteratureReference:1254321] The protein import motor of mitochondria: unfolding and trapping of preproteins are distinct and separable functions of matrix Hsp70 [LiteratureReference:1254324] Differential requirement for the mitochondrial Hsp70-Tim44 complex in unfolding and translocation of preproteins [LiteratureReference:1254306] Sorting switch of mitochondrial presequence translocase involves coupling of motor module to respiratory chain [LiteratureReference:1267904] The role of Hsp70 in conferring unidirectionality on protein translocation into mitochondria [LiteratureReference:1267940] A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins [LiteratureReference:1267933] Dynamic interaction between Isp45 and mitochondrial hsp70 in the protein import system of the yeast mitochondrial inner membrane [LiteratureReference:1267923] Mitochondrial protein import: biochemical and genetic evidence for interaction of matrix hsp70 and the inner membrane protein MIM44 [LiteratureReference:1267890] Mitochondrial Hsp70/MIM44 complex facilitates protein import [LiteratureReference:2127552] Step-size analyses of the mitochondrial Hsp70 import motor reveal the Brownian ratchet in operation [LiteratureReference:2127666] Genetic Analysis of Complex Interactions Amongst Components of the Mitochondrial Import Motor and Translocon in Saccharomyces cerevisiae [LiteratureReference:2127674] Direct interaction of mitochondrial targeting presequences with purified components of the TIM23 protein complex
modified	[InstanceEdit:1252340] May, B, 2011-04-27 [InstanceEdit:1254318] May, B, 2011-04-29 [InstanceEdit:1258391] May, B, 2011-05-03 [InstanceEdit:1268018] May, B, 2011-05-09 [InstanceEdit:1977303] May, B, 2011-11-08 [InstanceEdit:2010553] May, B, 2011-11-22 [InstanceEdit:2108992] May, B, 2012-02-12 [InstanceEdit:2127546] May, B, 2012-02-15 [InstanceEdit:2127553] May, B, 2012-02-15 [InstanceEdit:2127663] May, B, 2012-02-17 [InstanceEdit:5257491] May, B, 2014-02-06 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TIM23 PAM complex translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix
output	[DefinedSet:1252212] Cargo of TIM23 PAM [mitochondrial matrix] [Saccharomyces cerevisiae] [Complex:1252229] TIM23 Complex [mitochondrial inner membrane] [Saccharomyces cerevisiae] [SimpleEntity:113581] ADP [mitochondrial matrix] [SimpleEntity:113548] Pi [mitochondrial matrix]
precedingEvent	[Reaction:1252255] TOM40:TOM70 complex translocates proteins from the cytosol to the mitochondrial intermembrane space [Saccharomyces cerevisiae]
releaseDate	2012-03-13
reviewed	[InstanceEdit:1914221] D'Eustachio, P, 2011-11-01 [InstanceEdit:2108993] Endo, T, 2012-02-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:68322] Saccharomyces cerevisiae
stableIdentifier	[StableIdentifier:2158107] R-SCE-1252253.3
summation	[Summation:1258368] The TIM23 complex transports precursor proteins across the i...
(inferredFrom)	[Reaction:1299475] TIMM23 PAM translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix [Homo sapiens]
(replacementInstances)	[_Deleted:9697205] Deletion of instance: 1252265
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