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Details on Person Cleavage of P-ERBB4jmA isoforms by ADAM17

Class:Id	Reaction:1251992
_displayName	Cleavage of P-ERBB4jmA isoforms by ADAM17
_doRelease	TRUE
_timestamp	2019-03-05 19:37:14
authored	[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04 [InstanceEdit:9638819] Stern, David F, 2019-02-21
catalystActivity	[CatalystActivity:1251983] metalloendopeptidase activity of ADAM17 [plasma membrane]
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:1251989] Orlic-Milacic, Marija, 2011-04-26
edited	[InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:9638824] Orlic-Milacic, Marija, 2019-03-05
inferredFrom	[Reaction:1251988] Cleavage of P-ERBB4jmA isoforms by Adam17 [Homo sapiens]
input	[DefinedSet:1843077] p-ERBB4 JM-A homodimers [plasma membrane] [Homo sapiens]
isChimeric	FALSE
modified	[InstanceEdit:1258477] Orlic-Milacic, Marija, 2011-05-04 [InstanceEdit:1266734] Orlic-Milacic, Marija, 2011-05-06 [InstanceEdit:1307854] Orlic-Milacic, Marija, 2011-05-30 [InstanceEdit:1493109] Orlic-Milacic, Marija, 2011-08-15 [InstanceEdit:1549539] Orlic-Milacic, Marija, 2011-08-29 [InstanceEdit:1843079] Orlic-Milacic, M, 2011-10-27 [InstanceEdit:1977294] Orlic-Milacic, M, 2011-11-07 [InstanceEdit:1979912] Orlic-Milacic, M, 2011-11-08 [InstanceEdit:2104984] Orlic-Milacic, M, 2012-02-08 [InstanceEdit:9607288] Orlic-Milacic, Marija, 2018-05-01 [InstanceEdit:9638822] Orlic-Milacic, Marija, 2019-03-05 [InstanceEdit:9638825] Orlic-Milacic, Marija, 2019-03-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Cleavage of P-ERBB4jmA isoforms by ADAM17
output	[DefinedSet:1251970] ERBB4_ECD [extracellular region] [Homo sapiens] [DefinedSet:1251960] ERBB4m80 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1250315] Trans-autophosphorylation of ERBB4 homodimers [Homo sapiens] [Reaction:1250220] Homodimerization of ERBB4 [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1979910] Harris, RC, 2011-11-11 [InstanceEdit:1979909] Zeng, F, 2011-11-11 [InstanceEdit:2104982] Earp HS, 3rd, 2012-02-20 [InstanceEdit:2104979] Misior, AM, 2012-02-20
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016184] R-HSA-1251992.4
summation	[Summation:1251993] Phosphorylated ligand-bound homodimers of ERBB4 JM-A isoform...
(hasEvent)	[Pathway:1251985] Nuclear signaling by ERBB4 [Homo sapiens]
(precedingEvent)	[Reaction:1251997] Cleavage of ERBB4m80 by gamma-scretase complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779456] Update Tracker - [Reaction:1251992] Cleavage of P-ERBB4jmA isoforms by ADAM17 - v65:[modifyText, removeLiteratureReference]
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