Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person EGF:p-EGFR:p-ERBB2:PLCG1 [plasma membrane]

Class:IdComplex:1251942
_displayNameEGF:p-EGFR:p-ERBB2:PLCG1 [plasma membrane]
_timestamp2012-04-27 18:27:11
compartment[Compartment:876] plasma membrane
created[InstanceEdit:1251935] Orlic-Milacic, Marija, 2011-04-25
hasComponent
isChimericFALSE
modified[InstanceEdit:1474193] Orlic-Milacic, Marija, 2011-08-05
[InstanceEdit:1474296] Orlic-Milacic, Marija, 2011-08-05
[InstanceEdit:1963596] Orlic-Milacic, M, 2011-11-03
[InstanceEdit:2008068] Orlic-Milacic, M, 2011-11-21
[InstanceEdit:2213009] Matthews, L, 2012-04-27
nameEGF:p-EGFR:p-ERBB2:PLCG1
EGF:p-6Y-EGFR:p-6Y-ERBB2:PLCG1
Phospholipase C gamma 1:P-ERBB2:P-EGFR
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2017438] R-HSA-1251942.1
(input)[Reaction:1251922] PLCG1 phosphorylation by p-EGFR:p-ERBB2 [Homo sapiens]
(normalEntity)[EntityFunctionalStatus:9655374] gain_of_function of Phosphorylated ERBB2 L755S,(ERBB2 L755M,ERBB2 L755W):EGFR heterodimer:PLCG1 [plasma membrane]
[EntityFunctionalStatus:9655670] gain_of_function of Phosphorylated ERBB2 P780_Y781insGSP:EGFR heterodimer:PLCG1 [plasma membrane]
[EntityFunctionalStatus:9655671] gain_of_function of Phosphorylated ERBB2 V777L,(ERBB2 V777M,ERBB2 V777E):EGFR heterodimer:PLCG1 [plasma membrane]
[EntityFunctionalStatus:9655672] gain_of_function of Phosphorylated ERBB2 H878Y,(ERBB2 H878R):EGFR heterodimer:PLCG1 [plasma membrane]
[EntityFunctionalStatus:9655673] gain_of_function of Phosphorylated ERBB2 V842I,(ERBB2 V842E):EGFR heterodimer:PLCG1 [plasma membrane]
[EntityFunctionalStatus:9655674] gain_of_function of Phosphorylated ERBB2 D769H,(ERBB2 D769Y,ERBB2 D769N):EGFR heterodimer:PLCG1 [plasma membrane]
[EntityFunctionalStatus:9655676] gain_of_function of Phosphorylated ERBB2 I767M:EGFR heterodimer:PLCG1 [plasma membrane]
[EntityFunctionalStatus:9655677] gain_of_function of Phosphorylated ERBB2 R896C,(ERBB2 R896H):EGFR heterodimer:PLCG1 [plasma membrane]
[EntityFunctionalStatus:9665042] gain_of_function of p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR:PLCG1 [plasma membrane]
[EntityFunctionalStatus:9665462] gain_of_function of p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:PLCG1 [plasma membrane]
List all 11 refering instances
(output)[Reaction:1251944] PLCG1 binds to p-ERBB2:p-EGFR [Homo sapiens]
(physicalEntity)[CatalystActivity:1251945] protein tyrosine kinase activity of EGF:p-EGFR:p-ERBB2:PLCG1 [plasma membrane]
(updatedInstance)[_UpdateTracker:9872448] Update Tracker - [Complex:1251942] EGF:p-EGFR:p-ERBB2:PLCG1 [plasma membrane] - v41:[removeCompartment, updateContainedComponent]
[_UpdateTracker:9873207] Update Tracker - [Complex:1251942] EGF:p-EGFR:p-ERBB2:PLCG1 [plasma membrane] - v42:[updateContainedComponent]
[_UpdateTracker:9878818] Update Tracker - [Complex:1251942] EGF:p-EGFR:p-ERBB2:PLCG1 [plasma membrane] - v44:[updateContainedComponent]
[_UpdateTracker:9894756] Update Tracker - [Complex:1251942] EGF:p-EGFR:p-ERBB2:PLCG1 [plasma membrane] - v57:[updateContainedComponent]
[Change default viewing format]
No pathways have been reviewed or authored by EGF:p-EGFR:p-ERBB2:PLCG1 [plasma membrane] (1251942)
Follow Reactome