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Details on Person PLCG1 phosphorylation by p-EGFR:p-ERBB2

Class:Id	Reaction:1251922
_displayName	PLCG1 phosphorylation by p-EGFR:p-ERBB2
_doRelease	TRUE
_timestamp	2019-07-22 15:13:55
authored	[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04
catalystActivity	[CatalystActivity:1251945] protein tyrosine kinase activity of EGF:p-EGFR:p-ERBB2:PLCG1 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1251935] Orlic-Milacic, Marija, 2011-04-25
edited	[InstanceEdit:1972361] Matthews, L, 2011-11-07
inferredFrom	[Reaction:1251929] Plcg1 phosphorylation by P-ERBB2:P-EGFR [Homo sapiens]
input	[Complex:1251942] EGF:p-EGFR:p-ERBB2:PLCG1 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1251927] The erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potency [LiteratureReference:1361839] The relationship between human epidermal growth-like factor receptor expression and cellular transformation in NIH3T3 cells
modified	[InstanceEdit:1280207] Orlic-Milacic, Marija, 2011-05-12 [InstanceEdit:1361842] Orlic-Milacic, Marija, 2011-06-03 [InstanceEdit:1370851] Orlic-Milacic, Marija, 2011-07-04 [InstanceEdit:1474296] Orlic-Milacic, Marija, 2011-08-05 [InstanceEdit:1963599] Orlic-Milacic, M, 2011-11-03 [InstanceEdit:1972362] Orlic-Milacic, M, 2011-11-04 [InstanceEdit:9654887] Orlic-Milacic, Marija, 2019-07-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PLCG1 phosphorylation by p-EGFR:p-ERBB2
output	[EntityWithAccessionedSequence:167679] p-4Y-PLCG1 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [CandidateSet:1963587] Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1251944] PLCG1 binds to p-ERBB2:p-EGFR [Homo sapiens] [Reaction:1963582] Trans-autophosphorylation of ERBB2 heterodimers [Homo sapiens] [Reaction:1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1972347] Neckers, LM, 2011-11-11 [InstanceEdit:1972346] Xu, W, 2011-11-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016448] R-HSA-1251922.3
summation	[Summation:1251934] Phospholipase C gamma 1 (PLCG1) is phosphorylated by phospho...
(hasEvent)	[Pathway:1251932] PLCG1 events in ERBB2 signaling [Homo sapiens]
(normalReaction)	[Reaction:9665032] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1 [Homo sapiens] [Reaction:9665411] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1 [Homo sapiens] [Reaction:9665704] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1 [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9866010] Futile Cycle: PLCG1 phosphorylation by p-EGFR:p-ERBB2 [NegativePrecedingEvent:9866011] Futile Cycle: PLCG1 phosphorylation by p-EGFR:p-ERBB2 [NegativePrecedingEvent:9866019] Futile Cycle: PLCG1 phosphorylation by p-EGFR:p-ERBB2 [NegativePrecedingEvent:9866025] Futile Cycle: PLCG1 phosphorylation by p-EGFR:p-ERBB2 [NegativePrecedingEvent:9866034] Futile Cycle: PLCG1 phosphorylation by p-EGFR:p-ERBB2 [NegativePrecedingEvent:9866038] Futile Cycle: PLCG1 phosphorylation by p-EGFR:p-ERBB2 [NegativePrecedingEvent:9866039] Futile Cycle: PLCG1 phosphorylation by p-EGFR:p-ERBB2 [NegativePrecedingEvent:9866040] Futile Cycle: PLCG1 phosphorylation by p-EGFR:p-ERBB2 [NegativePrecedingEvent:9866053] Futile Cycle: PLCG1 phosphorylation by p-EGFR:p-ERBB2
(updatedInstance)	[_UpdateTracker:9777630] Update Tracker - [Reaction:1251922] PLCG1 phosphorylation by p-EGFR:p-ERBB2 - v70:[modifyText]
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No pathways have been reviewed or authored by PLCG1 phosphorylation by p-EGFR:p-ERBB2 (1251922)