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Details on Person RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers

Class:Id	Reaction:1250498
_displayName	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers
_doRelease	TRUE
_timestamp	2024-07-16 19:49:57
authored	[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04
catalystActivity	[CatalystActivity:1250482] guanyl-nucleotide exchange factor activity of EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:1250503] Orlic-Milacic, Marija, 2011-04-21
edited	[InstanceEdit:1972361] Matthews, L, 2011-11-07
inferredFrom	[Reaction:1250468] Ras guanyl-nucleotide exchange mediated by Sos1 in complex with GRB2 and P-Erbb2mut [Homo sapiens]
input	[Complex:109796] p21 RAS:GDP [plasma membrane] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1358725] Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2
modified	[InstanceEdit:1251950] Orlic-Milacic, Marija, 2011-04-25 [InstanceEdit:1358782] Orlic-Milacic, Marija, 2011-06-02 [InstanceEdit:1370853] Orlic-Milacic, Marija, 2011-07-04 [InstanceEdit:1474296] Orlic-Milacic, Marija, 2011-08-05 [InstanceEdit:1972362] Orlic-Milacic, M, 2011-11-04 [InstanceEdit:2006496] Orlic-Milacic, M, 2011-11-21 [InstanceEdit:2008069] Orlic-Milacic, M, 2011-11-21 [InstanceEdit:9655825] Orlic-Milacic, Marija, 2019-07-26 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9915824] D'Eustachio, Peter, 2024-07-16
name	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers
output	[Complex:109783] p21 RAS:GTP [plasma membrane] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol]
precedingEvent	[Reaction:1250488] GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer [Homo sapiens] [Reaction:1963582] Trans-autophosphorylation of ERBB2 heterodimers [Homo sapiens] [Reaction:1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1972347] Neckers, LM, 2011-11-11 [InstanceEdit:1972346] Xu, W, 2011-11-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016337] R-HSA-1250498.4
summation	[Summation:1250460] SOS1 bound to GRB2 in complex with phosphorylated ERBB2:EGFR...
(hasEvent)	[Pathway:1963640] GRB2 events in ERBB2 signaling [Homo sapiens]
(normalReaction)	[Reaction:9665009] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR [Homo sapiens] [Reaction:9665408] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2 [Homo sapiens] [Reaction:9665707] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777591] Update Tracker - [Reaction:1250498] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. - v70:[modifyText]
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No pathways have been reviewed or authored by RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers (1250498)