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Details on Person GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer

Class:Id	Reaction:1250488
_displayName	GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer
_doRelease	TRUE
_timestamp	2024-03-20 23:46:31
authored	[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1250503] Orlic-Milacic, Marija, 2011-04-21
edited	[InstanceEdit:1972361] Matthews, L, 2011-11-07
inferredFrom	[Reaction:1250475] Direct recruitment of GRB2:Sos1 to P-Erbb2mut dimer [Homo sapiens]
input	[Complex:109797] GRB2-1:SOS1 [cytosol] [Homo sapiens] [CandidateSet:1963587] Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1250467] Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu
modified	[InstanceEdit:1251950] Orlic-Milacic, Marija, 2011-04-25 [InstanceEdit:1474296] Orlic-Milacic, Marija, 2011-08-05 [InstanceEdit:1963621] Orlic-Milacic, M, 2011-11-03 [InstanceEdit:1972362] Orlic-Milacic, M, 2011-11-04 [InstanceEdit:2006493] Orlic-Milacic, M, 2011-11-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9866055] Orlic-Milacic, Marija, 2024-03-20
name	GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer
negativePrecedingEvent	[NegativePrecedingEvent:9866037] Futile Cycle: ERBB2 promotes PTK6 autophosphorylation [NegativePrecedingEvent:9866011] Futile Cycle: PLCG1 phosphorylation by p-EGFR:p-ERBB2
output	[Complex:1250505] EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1963582] Trans-autophosphorylation of ERBB2 heterodimers [Homo sapiens] [Reaction:1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 [Homo sapiens] [Reaction:1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers [Homo sapiens] [Reaction:1963586] SRC family kinases phosphorylate ERBB2 [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1972347] Neckers, LM, 2011-11-11 [InstanceEdit:1972346] Xu, W, 2011-11-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016681] R-HSA-1250488.3
summation	[Summation:1250497] Phosphorylated ERBB2:EGFR heterodimer recruits GRB2:SOS1 com...
(hasEvent)	[Pathway:1963640] GRB2 events in ERBB2 signaling [Homo sapiens]
(normalReaction)	[Reaction:9665000] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:SOS1 [Homo sapiens] [Reaction:9665409] GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR [Homo sapiens] [Reaction:9665698] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind GRB2:SOS1 [Homo sapiens]
(precedingEvent)	[Reaction:1250498] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers [Homo sapiens] [Reaction:5672965] RAS GEFs promote RAS nucleotide exchange [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777516] Update Tracker - [Reaction:1250488] GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer - v70:[modifyText]
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No pathways have been reviewed or authored by GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer (1250488)