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Details on Person Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers

Class:Id	Reaction:1250486
_displayName	Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers
_doRelease	TRUE
_timestamp	2011-11-23 11:17:02
authored	[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1250503] Orlic-Milacic, Marija, 2011-04-21
edited	[InstanceEdit:1972361] Matthews, L, 2011-11-07
inferredFrom	[Reaction:1250500] Recruitment of GRB2:Sos1 to P-Shc1:P-Erbb2mut complex [Homo sapiens]
input	[Complex:1250194] p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] [Homo sapiens] [Complex:109797] GRB2-1:SOS1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1250467] Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu
modified	[InstanceEdit:1251950] Orlic-Milacic, Marija, 2011-04-25 [InstanceEdit:1370855] Orlic-Milacic, Marija, 2011-07-04 [InstanceEdit:1474296] Orlic-Milacic, Marija, 2011-08-05 [InstanceEdit:1972362] Orlic-Milacic, M, 2011-11-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers
output	[Complex:1250479] GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1250195] SHC1 phosphorylation by ERBB2 heterodimers [Homo sapiens] [Reaction:1963578] SHC1 binds phosphorylated ERBB2 heterodimers [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1972347] Neckers, LM, 2011-11-11 [InstanceEdit:1972346] Xu, W, 2011-11-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016693] R-HSA-1250486.2
summation	[Summation:1250484] Phosphorylated SHC1 bound to phosphorylated ERBB2 dimers rec...
(hasEvent)	[Pathway:1250196] SHC1 events in ERBB2 signaling [Homo sapiens]
(normalReaction)	[Reaction:9634402] Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 homodimer [Homo sapiens] [Reaction:9664983] Phosphorylated heterodimers of ERBB2 KD mutants recruit GRB2:SOS1 through SHC1 [Homo sapiens] [Reaction:9665413] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR recruit GRB2:SOS1 through SHC1 [Homo sapiens] [Reaction:9665699] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants recruit GRB2:SOS1 through SHC1 [Homo sapiens]
(precedingEvent)	[Reaction:1250463] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers [Homo sapiens] [Reaction:5672965] RAS GEFs promote RAS nucleotide exchange [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777532] Update Tracker - [Reaction:1250486] Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers - v70:[modifyText]
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