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Details on Person Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu

Class:Id	LiteratureReference:1250467
_displayName	Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu
_timestamp	2011-04-21 14:33:20
author	[Person:1250507] Xie, Y [Person:1250473] Pendergast, AM [Person:199335] Hung, MC
created	[InstanceEdit:1250503] Orlic-Milacic, Marija, 2011-04-21
journal	J Biol Chem
pages	30717-24
pubMedIdentifier	8530511
title	Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu
volume	270
year	1995
(literatureReference)	[Reaction:1250463] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers [Homo sapiens] [Reaction:1250468] Ras guanyl-nucleotide exchange mediated by Sos1 in complex with GRB2 and P-Erbb2mut [Homo sapiens] [Reaction:1250472] Ras guanyl-nucleotide exchange mediated by Sos1 bound to GRB2 in complex with P-Shc1:P-Erbb2mut [Homo sapiens] [Reaction:1250475] Direct recruitment of GRB2:Sos1 to P-Erbb2mut dimer [Homo sapiens] [Reaction:1250486] Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers [Homo sapiens] [Reaction:1250488] GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer [Homo sapiens] [Reaction:1250500] Recruitment of GRB2:Sos1 to P-Shc1:P-Erbb2mut complex [Homo sapiens]
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