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Details on Person RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4

Class:Id	Reaction:1250383
_displayName	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
_doRelease	TRUE
_timestamp	2019-03-05 19:37:19
authored	[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04 [InstanceEdit:9638819] Stern, David F, 2019-02-21
catalystActivity	[CatalystActivity:1250381] guanyl-nucleotide exchange factor activity of GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:1250386] Orlic-Milacic, Marija, 2011-04-18
edited	[InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:9638824] Orlic-Milacic, Marija, 2019-03-05
input	[Complex:109796] p21 RAS:GDP [plasma membrane] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1250369] A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis
modified	[InstanceEdit:1367813] Orlic-Milacic, Marija, 2011-06-28 [InstanceEdit:1367820] Orlic-Milacic, Marija, 2011-06-28 [InstanceEdit:1977294] Orlic-Milacic, M, 2011-11-07 [InstanceEdit:1979912] Orlic-Milacic, M, 2011-11-08 [InstanceEdit:1981185] Orlic-Milacic, M, 2011-11-09 [InstanceEdit:2006488] Orlic-Milacic, M, 2011-11-21 [InstanceEdit:2104984] Orlic-Milacic, M, 2012-02-08 [InstanceEdit:9638822] Orlic-Milacic, Marija, 2019-03-05 [InstanceEdit:9638825] Orlic-Milacic, Marija, 2019-03-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
output	[Complex:109783] p21 RAS:GTP [plasma membrane] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol]
precedingEvent	[Reaction:1250380] Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers [Homo sapiens] [Reaction:1250348] Phosphorylation of SHC1 by ERBB4 homodimers [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1979910] Harris, RC, 2011-11-11 [InstanceEdit:1979909] Zeng, F, 2011-11-11 [InstanceEdit:2104982] Earp HS, 3rd, 2012-02-20 [InstanceEdit:2104979] Misior, AM, 2012-02-20
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016565] R-HSA-1250383.3
summation	[Summation:1250384] SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 activa...
(hasEvent)	[Pathway:1250347] SHC1 events in ERBB4 signaling [Homo sapiens]
(precedingEvent)	[Reaction:5672965] RAS GEFs promote RAS nucleotide exchange [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779447] Update Tracker - [Reaction:1250383] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 - v65:[modifyText]
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No pathways have been reviewed or authored by RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (1250383)