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Details on Person p85 subunit of PI3K (PIK3R1) directly binds to any of the tw...
| Class:Id | Summation:1250349 |
|---|---|
| _displayName | p85 subunit of PI3K (PIK3R1) directly binds to any of the tw... |
| _timestamp | 2016-03-10 17:31:55 |
| created | [InstanceEdit:1250362] Orlic-Milacic, Marija, 2011-04-18 |
| modified | [InstanceEdit:1254412] Orlic-Milacic, Marija, 2011-04-29 [InstanceEdit:1370869] Orlic-Milacic, Marija, 2011-07-04 [InstanceEdit:1963602] Orlic-Milacic, M, 2011-11-03 [InstanceEdit:8863999] Orlic-Milacic, Marija, 2016-03-10 |
| text | p85 subunit of PI3K (PIK3R1) directly binds to any of the two phosphorylated ERBB4 CYT1 isoforms in complex with ERBB2 through interaction with a phosphorylated tyrosine residue in the C-tail of ERBB4 CYT1 (Y1056 in ERBB4 JM-A CYT1; Y1046 in ERBB4 JM-B CYT1). Catalytic subunit p110 of PI3K (PIK3CA) is constitutively associated with PIK3R1, and binding of PIK3R1 to the phosphorylated ERBB2:ERBB4cyt1 heterodimer results in a conformational change that activates the PI3K. |
| (summation) | [Reaction:1250346] Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers [Homo sapiens] |
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No pathways have been reviewed or authored by p85 subunit of PI3K (PIK3R1) directly binds to any of the tw... (1250349)
