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Details on Person Phosphorylation of SHC1 by ERBB4 homodimers

Class:Id	Reaction:1250348
_displayName	Phosphorylation of SHC1 by ERBB4 homodimers
_doRelease	TRUE
_timestamp	2019-03-05 19:37:18
authored	[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04 [InstanceEdit:9638819] Stern, David F, 2019-02-21
catalystActivity	[CatalystActivity:1250352] protein tyrosine kinase activity of SHC1:p-ERBB4 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1250362] Orlic-Milacic, Marija, 2011-04-18
edited	[InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:9638824] Orlic-Milacic, Marija, 2019-03-05
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:1250359] SHC1:p-ERBB4 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1250369] A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis
modified	[InstanceEdit:1250379] Orlic-Milacic, Marija, 2011-04-18 [InstanceEdit:1257610] Orlic-Milacic, Marija, 2011-05-02 [InstanceEdit:1258430] Orlic-Milacic, Marija, 2011-05-03 [InstanceEdit:1367069] Orlic-Milacic, Marija, 2011-06-28 [InstanceEdit:1367819] Orlic-Milacic, Marija, 2011-06-28 [InstanceEdit:1977294] Orlic-Milacic, M, 2011-11-07 [InstanceEdit:1979912] Orlic-Milacic, M, 2011-11-08 [InstanceEdit:2104984] Orlic-Milacic, M, 2012-02-08 [InstanceEdit:9638822] Orlic-Milacic, Marija, 2019-03-05 [InstanceEdit:9638825] Orlic-Milacic, Marija, 2019-03-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of SHC1 by ERBB4 homodimers
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:1250343] p-Y349,350-SHC1:p-ERBB4 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1250357] SHC1 binds P-ERBB4 isoform dimers [Homo sapiens] [Reaction:1250315] Trans-autophosphorylation of ERBB4 homodimers [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1979910] Harris, RC, 2011-11-11 [InstanceEdit:1979909] Zeng, F, 2011-11-11 [InstanceEdit:2104982] Earp HS, 3rd, 2012-02-20 [InstanceEdit:2104979] Misior, AM, 2012-02-20
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016501] R-HSA-1250348.3
summation	[Summation:1250344] After binding ERBB4 homodimers, SHC1 gets phosphorylated on ...
(hasEvent)	[Pathway:1250347] SHC1 events in ERBB4 signaling [Homo sapiens]
(precedingEvent)	[Reaction:1250380] Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779301] Update Tracker - [Reaction:1250348] Phosphorylation of SHC1 by ERBB4 homodimers - v65:[modifyText]
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