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Details on Person SHC1 phosphorylation by ERBB2 heterodimers

Class:IdReaction:1250195
_displayNameSHC1 phosphorylation by ERBB2 heterodimers
_doReleaseTRUE
_timestamp2011-11-23 11:11:39
authored[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04
catalystActivity[CatalystActivity:1250198] protein tyrosine kinase activity of SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:984] extracellular region
created[InstanceEdit:1250197] Orlic-Milacic, Marija, 2011-04-14
edited[InstanceEdit:1972361] Matthews, L, 2011-11-07
input[Complex:1248746] SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:180308] Potent SHC tyrosine phosphorylation by epidermal growth factor at low receptor density or in the absence of receptor autophosphorylation sites
[LiteratureReference:1248777] Shc products are substrates of erbB-2 kinase
modified[InstanceEdit:1306987] Orlic-Milacic, Marija, 2011-05-27
[InstanceEdit:1358750] Orlic-Milacic, Marija, 2011-06-02
[InstanceEdit:1368198] Orlic-Milacic, Marija, 2011-06-30
[InstanceEdit:1370860] Orlic-Milacic, Marija, 2011-07-04
[InstanceEdit:1963562] Orlic-Milacic, M, 2011-11-03
[InstanceEdit:1963628] Orlic-Milacic, M, 2011-11-03
[InstanceEdit:1972362] Orlic-Milacic, M, 2011-11-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameSHC1 phosphorylation by ERBB2 heterodimers
output[Complex:1250194] p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2011-12-06
reviewed[InstanceEdit:1972347] Neckers, LM, 2011-11-11
[InstanceEdit:1972346] Xu, W, 2011-11-11
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2016416] R-HSA-1250195.2
summation[Summation:1358749] Once bound to ERBB2 heterodimers, SHC1 is phosphorylated on ...
(hasEvent)[Pathway:1250196] SHC1 events in ERBB2 signaling [Homo sapiens]
(normalReaction)[Reaction:9634390] ERBB2 homodimer phosphorylates SHC1 [Homo sapiens]
[Reaction:9664976] Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1 [Homo sapiens]
[Reaction:9665406] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate SHC1 [Homo sapiens]
[Reaction:9665705] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1 [Homo sapiens]
(precedingEvent)[Reaction:1250486] Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers [Homo sapiens]
(updatedInstance)[_UpdateTracker:9777653] Update Tracker - [Reaction:1250195] SHC1 phosphorylation by ERBB2 heterodimers - v70:[modifyText]
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No pathways have been reviewed or authored by SHC1 phosphorylation by ERBB2 heterodimers (1250195)
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