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Details on Person Binding of PI3K to ERBB2:p-ERBB3 heterodimer

Class:Id	Reaction:1250189
_displayName	Binding of PI3K to ERBB2:p-ERBB3 heterodimer
_doRelease	TRUE
_timestamp	2024-03-20 23:45:57
authored	[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:1250192] Orlic-Milacic, Marija, 2011-04-14
edited	[InstanceEdit:1972361] Matthews, L, 2011-11-07
input	[CandidateSet:1963572] Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] [Homo sapiens] [Complex:1806218] PIK3CA:PIK3R1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1248769] Mapping ErbB receptors on breast cancer cell membranes during signal transduction [LiteratureReference:1358728] Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941
modified	[InstanceEdit:1251950] Orlic-Milacic, Marija, 2011-04-25 [InstanceEdit:1963596] Orlic-Milacic, M, 2011-11-03 [InstanceEdit:1972362] Orlic-Milacic, M, 2011-11-04 [InstanceEdit:1972370] Orlic-Milacic, M, 2011-11-04 [InstanceEdit:2006490] Orlic-Milacic, M, 2011-11-21 [InstanceEdit:8863999] Orlic-Milacic, Marija, 2016-03-10 [InstanceEdit:9654297] Orlic-Milacic, Marija, 2019-07-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9866055] Orlic-Milacic, Marija, 2024-03-20
name	Binding of PI3K to ERBB2:p-ERBB3 heterodimer
negativePrecedingEvent	[NegativePrecedingEvent:9866014] Futile Cycle: ERBB2 promotes PTK6 autophosphorylation [NegativePrecedingEvent:9866015] Negative relationship: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248
output	[Complex:1250508] NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1963582] Trans-autophosphorylation of ERBB2 heterodimers [Homo sapiens] [Reaction:1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 [Homo sapiens] [Reaction:1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers [Homo sapiens] [Reaction:1963586] SRC family kinases phosphorylate ERBB2 [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1972347] Neckers, LM, 2011-11-11 [InstanceEdit:1972346] Xu, W, 2011-11-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016446] R-HSA-1250189.5
summation	[Summation:1250190] Membrane associated p85 subunit of PI3K (PIK3R1) binds to ph...
(hasEvent)	[Pathway:1963642] PI3K events in ERBB2 signaling [Homo sapiens]
(normalReaction)	[Reaction:9664646] Phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 bind PI3K [Homo sapiens]
(precedingEvent)	[Reaction:1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 [Homo sapiens] [Reaction:2316434] PI3K phosphorylates PIP2 to PIP3 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777528] Update Tracker - [Reaction:1250189] Binding of PI3K to ERBB2:p-ERBB3 heterodimer - v70:[modifyText] [_UpdateTracker:9783020] Update Tracker - [Reaction:1250189] Binding of PI3K to ERBB2:p-ERBB3 heterodimer - v57:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
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