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Details on Person Trans-autophosphorylation of ERBB2:ERBB3 heterodimer

Class:Id	Reaction:1248745
_displayName	Trans-autophosphorylation of ERBB2:ERBB3 heterodimer
_doRelease	FALSE
_timestamp	2016-07-15 23:48:55
catalystActivity	[CatalystActivity:1248747] protein tyrosine kinase activity of NRG1/2:ERBB3:p-Y877-ERBB2 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1248751] Orlic-Milacic, Marija, 2011-04-13
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:1810433] NRG1/2:ERBB3:p-Y877-ERBB2 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1248733] Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions [LiteratureReference:1250127] Identification of c-erbB-3 binding sites for phosphatidylinositol 3'-kinase and SHC using an EGF receptor/c-erbB-3 chimera [LiteratureReference:1250125] Roles of mitogen-activated protein kinase and phosphoinositide 3'-kinase in ErbB2/ErbB3 coreceptor-mediated heregulin signaling [LiteratureReference:1250122] Neuregulin-1 only induces trans-phosphorylation between ErbB receptor heterodimer partners [LiteratureReference:1678599] Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3
modified	[InstanceEdit:1250216] Orlic-Milacic, Marija, 2011-04-14 [InstanceEdit:1358747] Orlic-Milacic, Marija, 2011-06-02 [InstanceEdit:1370866] Orlic-Milacic, Marija, 2011-07-04 [InstanceEdit:1678590] Orlic-Milacic, M, 2011-10-18 [InstanceEdit:1678603] Orlic-Milacic, M, 2011-10-18 [InstanceEdit:1810449] Orlic-Milacic, M, 2011-10-24 [InstanceEdit:8879177] Wu, G, 2016-07-15
name	Trans-autophosphorylation of ERBB2:ERBB3 heterodimer
output	[Complex:1248749] NRG1/2:p-10Y-ERBB3:p-Y,877-ERBB2 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:1247500] ERBB2 forms a heterodimer with activated ERBB3 [Homo sapiens] [Reaction:1247497] ERBB3 binds neuregulins [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8879928] R-HSA-1248745.1
summation	[Summation:1248750] After ERBB2 forms a heterodimer with neuregulin stimulated E...
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