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Details on Person Trans-autophosphorylation of ERBB2 homodimer

Class:IdReaction:1248694
_displayNameTrans-autophosphorylation of ERBB2 homodimer
_doReleaseTRUE
_timestamp2019-11-12 18:17:37
authored[InstanceEdit:9656339] Orlic-Milacic, Marija, 2019-07-31
catalystActivity[CatalystActivity:1248696] protein tyrosine kinase activity of ERBB2 homodimer [plasma membrane]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:984] extracellular region
created[InstanceEdit:1248683] Orlic-Milacic, Marija, 2011-04-12
disease[Disease:1500689] cancer
edited[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019-11-01
input[Complex:1227936] ERBB2 homodimer [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:1248697] Analysis of protein-protein interactions involved in the activation of the Shc/Grb-2 pathway by the ErbB-2 kinase
[LiteratureReference:1248688] Identification of autophosphorylation sites of HER2/neu
[LiteratureReference:9634297] The effects of trastuzumab on HER2-mediated cell signaling in CHO cells expressing human HER2
[LiteratureReference:1227966] Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab
modified[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:9634284] Orlic-Milacic, Marija, 2019-01-09
[InstanceEdit:9634293] Orlic-Milacic, Marija, 2019-01-09
[InstanceEdit:9634294] Orlic-Milacic, Marija, 2019-01-09
[InstanceEdit:9634302] Orlic-Milacic, Marija, 2019-01-09
[InstanceEdit:9634474] Orlic-Milacic, Marija, 2019-01-10
[InstanceEdit:9662688] Orlic-Milacic, Marija, 2019-09-23
[InstanceEdit:9665224] Orlic-Milacic, Marija, 2019-10-30
[InstanceEdit:9665326] Orlic-Milacic, Marija, 2019-10-30
[InstanceEdit:9666039] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9666040] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9666041] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9666042] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9667512] Orlic-Milacic, Marija, 2019-11-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameTrans-autophosphorylation of ERBB2 homodimer
normalReaction
output[Complex:1248686] p-ERBB2 homodimer [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
regulatedBy[NegativeRegulation:9652363] Negative regulation by 'ERBB2:trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane]'
[NegativeRegulation:9652348] Negative regulation by 'ERBB2:TKIs:ERBIN:HSP90:CDC37 [plasma membrane]'
releaseDate2019-12-10
reviewed[InstanceEdit:9662685] Kancha, Rama Krishna, 2019-09-16
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8902783] R-HSA-1248694.2
summation[Summation:1248687] ERBB2 homodimers trans-autophosphorylate to form phosphoryla...
(hasEvent)[Pathway:9634285] Constitutive Signaling by Overexpressed ERBB2 [Homo sapiens]
(precedingEvent)[Reaction:9634391] SHC1 binds phosphorylated ERBB2 homodimer [Homo sapiens]
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No pathways have been reviewed or authored by Trans-autophosphorylation of ERBB2 homodimer (1248694)
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