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Details on Person Trans-autophosphorylation of EGFRvIII mutant dimers

Class:Id	Reaction:1248655
_displayName	Trans-autophosphorylation of EGFRvIII mutant dimers
_doRelease	TRUE
_timestamp	2014-11-13 15:02:47
authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
catalystActivity	[CatalystActivity:1248647] protein tyrosine kinase activity of EGFRvIII mutant dimer [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:1248656] Orlic-Milacic, Marija, 2011-04-11
disease	[Disease:1500689] cancer
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
entityFunctionalStatus	[EntityFunctionalStatus:5638088] gain_of_function of EGFRvIII mutant dimer [plasma membrane]
input	[Complex:1248010] EGFRvIII mutant dimer [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1248637] Hypophosphorylation of residue Y1045 leads to defective downregulation of EGFRvIII [LiteratureReference:1248643] Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma
modified	[InstanceEdit:1643705] Orlic-Milacic, Marija, 2011-10-11 [InstanceEdit:1660495] Orlic-Milacic, Marija, 2011-10-13 [InstanceEdit:1667628] Orlic-Milacic, Marija, 2011-10-14 [InstanceEdit:1979631] Orlic-Milacic, Marija, 2011-11-08 [InstanceEdit:1990842] Orlic-Milacic, Marija, 2011-11-14 [InstanceEdit:1990860] Orlic-Milacic, Marija, 2011-11-14 [InstanceEdit:2023591] Matthews, L, 2011-12-09 [InstanceEdit:5638089] Orlic-Milacic, Marija, 2014-11-13 [InstanceEdit:5638128] Orlic-Milacic, Marija, 2014-11-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Trans-autophosphorylation of EGFRvIII mutant dimers
normalReaction	[Reaction:177934] EGFR autophosphorylation [Homo sapiens]
output	[Complex:1248654] p-5Y-EGFRvIII mutant dimer [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:1248002] Ligand-independent dimerization of EGFRvIII mutant [Homo sapiens] [Reaction:1247999] EGFRvIII mutant binds chaperone proteins HSP90 and CDC37 [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016176] R-HSA-1248655.2
summation	[Summation:1248645] Upon dimerization, EGFRvIII mutants trans-autophosphorylate ...
(hasEvent)	[Pathway:5637810] Constitutive Signaling by EGFRvIII [Homo sapiens]
(precedingEvent)	[Reaction:1225947] Binding of SHC1 to p-6Y-EGFR mutants [Homo sapiens] [Reaction:1225950] Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants [Homo sapiens] [Reaction:1226016] Binding of GRB2:GAB1 complex to ligand-responsive p-6Y-EGFR mutants [Homo sapiens] [Reaction:1247841] PLCG1 binds to ligand-responsive p-6Y-EGFR mutants [Homo sapiens] [Reaction:5637764] Binding of GRB2:GAB1 complex to p-EGFRvIII mutant [Homo sapiens] [Reaction:5637766] Binding of SHC1 to p-5Y-EGFRvIII [Homo sapiens] [Reaction:5637770] Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII [Homo sapiens] [Reaction:5637792] PLC-gamma 1 binds to p-EGFRvIII mutant [Homo sapiens] [FailedReaction:5637794] EGFRvIII does not bind CBL [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9846717] Update Tracker - [Reaction:1248655] Trans-autophosphorylation of EGFRvIII mutant dimers - v84:[modifyText]
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