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Details on Person Upon dimerization, EGFRvIII mutants trans-autophosphorylate ...
| Class:Id | Summation:1248645 |
|---|---|
| _displayName | Upon dimerization, EGFRvIII mutants trans-autophosphorylate ... |
| _timestamp | 2023-01-22 19:16:01 |
| created | [InstanceEdit:1248646] Orlic-Milacic, Marija, 2011-04-11 |
| modified | [InstanceEdit:9824815] Orlic-Milacic, Marija, 2023-01-22 |
| text | Upon dimerization, EGFRvIII mutants trans-autophosphorylate on tyrosine residues Y1016 i.e. Y992 in the mature protein, Y1092 i.e. Y1068 in the mature protein, Y1110 i.e. Y0186 in the mature protein, Y1172 i.e. Y1148 in the mature protein and Y1197 i.e. Y1173 in the mature protein, while the tyrosine residue Y1069 i.e. Y1045 in the mature protein, a docking site for CBL, remains either unphosphorylated or hypophosphorylated, allowing EGFRvIII to activate downstream signaling cascades while escaping downregulation. |
| (summation) | [Reaction:1248655] Trans-autophosphorylation of EGFRvIII mutant dimers [Homo sapiens] |
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No pathways have been reviewed or authored by Upon dimerization, EGFRvIII mutants trans-autophosphorylate ... (1248645)
