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Details on Person SLC4A1 exchanges cytosolic Cl- for extracellular HCO3-

Class:Id	Reaction:1247665
_displayName	SLC4A1 exchanges cytosolic Cl- for extracellular HCO3-
_doRelease	TRUE
_timestamp	2020-11-19 09:52:21
authored	[InstanceEdit:1247667] May, B, 2011-04-04
catalystActivity	[CatalystActivity:1237040] solute:inorganic anion antiporter activity of SLC4A1 dimer [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:1247651] May, B, 2011-04-05
edited	[InstanceEdit:1247667] May, B, 2011-04-04
input	[SimpleEntity:352022] Cl- [cytosol] [SimpleEntity:425425] HCO3- [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:1237464] A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers [LiteratureReference:1237501] Deficient HCO3- transport in an AE1 mutant with normal Cl- transport can be rescued by carbonic anhydrase II presented on an adjacent AE1 protomer [LiteratureReference:1237494] The asymmetry of chloride transport at 38 degrees C in human red blood cell membranes
modified	[InstanceEdit:2207685] May, B, 2012-04-27 [InstanceEdit:5252140] May, B, 2014-02-05 [InstanceEdit:9707445] Jassal, Bijay, 2020-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- Band 3 Anion Exchanger (AE1, SLC4A1) exchanges cytosolic chloride for extracellular bicarbonate
output	[SimpleEntity:188972] Cl- [extracellular region] [SimpleEntity:111627] HCO3- [cytosol]
releaseDate	2012-06-12
reverseReaction	[Reaction:1237038] SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- [Homo sapiens] [Reaction:1247665] SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- [Homo sapiens]
reviewed	[InstanceEdit:2207684] Jassal, B, 2012-04-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294822] R-HSA-1247665.3
summation	[Summation:1244358] The band 3 anion exchange protein (AE1, SLC4A1) exchanges ch...
(hasEvent)	[Pathway:1247673] Erythrocytes take up oxygen and release carbon dioxide [Homo sapiens]
(precedingEvent)	[Reaction:1475436] CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 [Homo sapiens]
(reverseReaction)	[Reaction:1237038] SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- [Homo sapiens]
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