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Details on Person ERBB2 forms a heterodimer with activated ERBB3

Class:Id	Reaction:1247500
_displayName	ERBB2 forms a heterodimer with activated ERBB3
_doRelease	FALSE
_timestamp	2016-07-15 23:49:36
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1247501] Orlic-Milacic, Marija, 2011-04-01
input	[Complex:1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] [Homo sapiens] [Complex:1247495] NRG1/2:ERBB3 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1248735] Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation [LiteratureReference:1248733] Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions
modified	[InstanceEdit:1248762] Orlic-Milacic, Marija, 2011-04-13 [InstanceEdit:1358775] Orlic-Milacic, Marija, 2011-06-02 [InstanceEdit:1370835] Orlic-Milacic, Marija, 2011-07-04 [InstanceEdit:8879177] Wu, G, 2016-07-15
name	ERBB2 forms a heterodimer with activated ERBB3
output	[Complex:1247502] NRG1/2:ERBB3:ERBB2 [plasma membrane] [Homo sapiens] [Complex:1225828] CDC37 [cytosol] [Homo sapiens] [Complex:1221657] HSP90 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:1358718] ERBIN [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1247497] ERBB3 binds neuregulins [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8899247] R-HSA-1247500.1
summation	[Summation:1358759] Neuregulin-activated ERBB3 forms a heterodimer with ERBB2. I...
(precedingEvent)	[Reaction:1248745] Trans-autophosphorylation of ERBB2:ERBB3 heterodimer [Homo sapiens] [Reaction:1810442] SRC family kinases phosphorylate ERBB2 (in complex with ERBB3) [Homo sapiens]
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No pathways have been reviewed or authored by ERBB2 forms a heterodimer with activated ERBB3 (1247500)