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Details on Person In mammals, the response to viral infection is mediated thro...

Class:IdSummation:1237376
_displayNameIn mammals, the response to viral infection is mediated thro...
_timestamp2011-05-23 20:19:29
created[InstanceEdit:1237388] Shamovsky, V, 2011-03-30
literatureReference[LiteratureReference:918292] TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA
[LiteratureReference:450151] Distinct molecular mechanism for initiating TRAF6 signalling
[LiteratureReference:918158] Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif
[LiteratureReference:918176] VISA is an adapter protein required for virus-triggered IFN-beta signaling
[LiteratureReference:918164] Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response
[LiteratureReference:1250128] A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response
[LiteratureReference:1267763] RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1
modified[InstanceEdit:1247366] Shamovsky, V, 2011-04-01
[InstanceEdit:1267864] Shamovsky, V, 2011-05-09
[InstanceEdit:1273407] Shamovsky, V, 2011-05-11
[InstanceEdit:1300654] Shamovsky, V, 2011-05-23
textIn mammals, the response to viral infection is mediated through direct and specific interaction between a TRAF-interaction motif (TIM) of IPS-1 and TRAFs, which can recruit other molecules into signaling complex [Ye H et al 2002, Xu LG et al 2005, Saha SK et al 2006, Konno H et al 2009]. IPS-1 harbors few distinct TIMs. One of the motifs is located at aa 143-PVQET-147 and binds both TRAF2 and TRAF3, while TRAF6 exclusively binds to aa 153-PGENSE-158 & 455-PEENEY-460 motifs. IPS-1 mediated response to viral infection in mammals requires:
  • TRAF6 to activate NFkB, MAPK and IRF7, but not IRF3.[Xu LG et al 2005, Yoshida R et al 2009, Konno H et al 2009].
  • TRAF3 to activate IRF3 and IRF7 [Saha SK et al 2006, Oganesyan G et al 2006].
  • TRAF2 to activate p38 MAPK and contribute to NFkB induction [Mikkelsen SS et al 2009, Xu LG et al 2005].

Predicted chicken TRAF2, TRAF3 and TRAF6 proteins show 75, 82 and 73% amino acid sequence identity to their human counterparts respectively. In this project we assume that chicken TRAF proteins function similar to mammalian TRAFs upon viral infection.

(summation)[Reaction:1227775] TRAF6/or TRAF2 interacts with IPS-1 [Gallus gallus]
[Reaction:1227891] TRAF3/or TRAF6 interacts with IPS-1 [Gallus gallus]
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