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Details on Person Once activated, IPS-1 recruits TRAFs (TNF receptor associate...

Class:IdSummation:1237353
_displayNameOnce activated, IPS-1 recruits TRAFs (TNF receptor associate...
_timestamp2011-05-11 04:04:39
created[InstanceEdit:1237388] Shamovsky, V, 2011-03-30
literatureReference[LiteratureReference:918292] TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA
[LiteratureReference:918164] Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response
[LiteratureReference:918158] Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif
[LiteratureReference:1250168] The NY-1 hantavirus Gn cytoplasmic tail coprecipitates TRAF3 and inhibits cellular interferon responses by disrupting TBK1-TRAF3 complex formation
modified[InstanceEdit:1247366] Shamovsky, V, 2011-04-01
[InstanceEdit:1267872] Shamovsky, V, 2011-05-09
[InstanceEdit:1273407] Shamovsky, V, 2011-05-11
textOnce activated, IPS-1 recruits TRAFs (TNF receptor associated factor protein family members) to the RIG-1/MDA5 receptor complex. TRAF3 and TRAF6 act as a scaffold for the assembly of the signaling complex composed of TBK1/ IKK epsilon, leading to the activation of transcription factors IRF3 and IRF7. TRAF6-induced activation of IRF is likely to be specific for IRF7, while TRAF3 is thought to activate both IRF3 and IRF7 [Konno H et al 2009, Oganesyan G et al 2006].


Transient transfection experiments in human embryonic kidney (HEK) 293 cells revealed that TRAF6 associates with IPS-1, TBK1, IKKi and TANK [Konno H et al 2009]. TRAF3 was also shown to form complexes with IPS-1, TBK1 and IKKi [Oganesyan G et al 2006, Alff PJ et al 2008, Saha SK et al 2006]

(summation)[Pathway:1227882] TRAF mediated activation of IRF [Gallus gallus]
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