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Details on Person CA4:Zn2+ hydrates CO2 to HCO3-

Class:Id	Reaction:1237047
_displayName	CA4:Zn2+ hydrates CO2 to HCO3-
_doRelease	TRUE
_timestamp	2020-11-19 09:51:44
authored	[InstanceEdit:1237008] May, B, 2011-03-24
catalystActivity	[CatalystActivity:1237049] carbonate dehydratase activity of CA4:Zn2+ [plasma membrane]
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:1237041] May, B, 2011-03-30
edited	[InstanceEdit:1237008] May, B, 2011-03-24
input	[SimpleEntity:1237009] CO2 [extracellular region] [SimpleEntity:109276] H2O [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:1237486] Carbonic anhydrase IV from human lung. Purification, characterization, and comparison with membrane carbonic anhydrase from human kidney [LiteratureReference:1237512] Human carbonic anhydrase IV: cDNA cloning, sequence comparison, and expression in COS cell membranes [LiteratureReference:1237497] Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions [LiteratureReference:1237487] Catalysis and inhibition of human carbonic anhydrase IV [LiteratureReference:1243058] Structure and mechanism of carbonic anhydrase [LiteratureReference:1638783] Carbonic anhydrase IV activity is localized on the exterior surface of human erythrocytes
modified	[InstanceEdit:1237538] May, B, 2011-03-31 [InstanceEdit:1243071] May, B, 2011-03-31 [InstanceEdit:1638784] May, B, 2011-10-07 [InstanceEdit:2197783] May, B, 2012-04-15 [InstanceEdit:2207685] May, B, 2012-04-27 [InstanceEdit:5252140] May, B, 2014-02-05 [InstanceEdit:9707445] Jassal, Bijay, 2020-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9863268] Stephan, Ralf, 2024-02-28
name	CA4:Zn2+ hydrates CO2 to HCO3- Carbonic anhydrase IV hydrates carbon dioxide to bicarbonate and a proton H2O + CO2 -> H+ + HCO3-
output	[SimpleEntity:351626] H+ [extracellular region] [SimpleEntity:425425] HCO3- [extracellular region]
precedingEvent	[Reaction:70967] IDH3 complex decarboxylates isocitrate [Homo sapiens] [Reaction:70971] ACO2 isomerizes citrate [Homo sapiens] [Reaction:450984] IDH2 dimer decarboxylates isocitrate [Homo sapiens] [Reaction:70971] ACO2 isomerizes citrate [Homo sapiens] [Reaction:450971] NNT dimer transfers proton from NADPH to NAD+ [Homo sapiens] [Reaction:71401] OGDH dimer decarboxylates 2-OG [Homo sapiens] [Reaction:70967] IDH3 complex decarboxylates isocitrate [Homo sapiens] [Reaction:9853499] DLD dimer dehydrogenates dihydrolipoyl [Homo sapiens] [Reaction:450984] IDH2 dimer decarboxylates isocitrate [Homo sapiens] [Reaction:70979] MDH2 dimer dehydrogenates MAL [Homo sapiens] [Reaction:450971] NNT dimer transfers proton from NADPH to NAD+ [Homo sapiens]
releaseDate	2012-06-12
reverseReaction	[Reaction:1237059] CA4:Zn2+ dehydrates HCO3- to CO2 [Homo sapiens] [Reaction:1237047] CA4:Zn2+ hydrates CO2 to HCO3- [Homo sapiens]
reviewed	[InstanceEdit:2207684] Jassal, B, 2012-04-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294747] R-HSA-1237047.4
summation	[Summation:1243063] Carbonic anhydrase IV (CA4) anchored to extracellular face o...
(hasEvent)	[Pathway:1237044] Erythrocytes take up carbon dioxide and release oxygen [Homo sapiens] [Pathway:1237061] Individual Reactions Catalyzed by Carbonic Anhydrases [Homo sapiens]
(reverseReaction)	[Reaction:1237059] CA4:Zn2+ dehydrates HCO3- to CO2 [Homo sapiens]
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No pathways have been reviewed or authored by CA4:Zn2+ hydrates CO2 to HCO3- (1237047)