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Details on Person AQP1 tetramer transports CO2 from extracellular region to cytosol

Class:Id	Reaction:1237042
_displayName	AQP1 tetramer transports CO2 from extracellular region to cytosol
_doRelease	TRUE
_timestamp	2020-11-19 09:51:11
authored	[InstanceEdit:1237008] May, B, 2011-03-24
catalystActivity	[CatalystActivity:1237058] carbon dioxide transmembrane transporter activity of AQP1 tetramer [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:1237041] May, B, 2011-03-30
edited	[InstanceEdit:1237008] May, B, 2011-03-24
input	[SimpleEntity:1237009] CO2 [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:1237002] Aquaporin-1 and HCO3(-)-Cl- transporter-mediated transport of CO2 across the human erythrocyte membrane [LiteratureReference:1236991] Relative CO2/NH3 selectivities of AQP1, AQP4, AQP5, AmtB, and RhAG [LiteratureReference:1237207] Red cell membrane CO2 permeability in normal human blood and in blood deficient in various blood groups, and effect of DIDS [LiteratureReference:1237220] Evidence that aquaporin 1 is a major pathway for CO2 transport across the human erythrocyte membrane [LiteratureReference:1237270] Effect of expressing the water channel aquaporin-1 on the CO2 permeability of Xenopus oocytes
modified	[InstanceEdit:1237326] May, B, 2011-03-30 [InstanceEdit:1244338] May, B, 2011-04-01 [InstanceEdit:1247651] May, B, 2011-04-05 [InstanceEdit:2197785] May, B, 2012-04-15 [InstanceEdit:2207685] May, B, 2012-04-27 [InstanceEdit:5252140] May, B, 2014-02-05 [InstanceEdit:9707445] Jassal, Bijay, 2020-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9863268] Stephan, Ralf, 2024-02-28
name	AQP1 tetramer transports CO2 from extracellular region to cytosol AQP1 passively tranlocates carbon dioxide from the extracellular region to the cytosol
output	[SimpleEntity:113528] CO2 [cytosol]
precedingEvent	[Reaction:70967] IDH3 complex decarboxylates isocitrate [Homo sapiens] [Reaction:70971] ACO2 isomerizes citrate [Homo sapiens] [Reaction:450984] IDH2 dimer decarboxylates isocitrate [Homo sapiens] [Reaction:70971] ACO2 isomerizes citrate [Homo sapiens] [Reaction:450971] NNT dimer transfers proton from NADPH to NAD+ [Homo sapiens] [Reaction:71401] OGDH dimer decarboxylates 2-OG [Homo sapiens] [Reaction:70967] IDH3 complex decarboxylates isocitrate [Homo sapiens] [Reaction:9853499] DLD dimer dehydrogenates dihydrolipoyl [Homo sapiens] [Reaction:450984] IDH2 dimer decarboxylates isocitrate [Homo sapiens] [Reaction:70979] MDH2 dimer dehydrogenates MAL [Homo sapiens] [Reaction:450971] NNT dimer transfers proton from NADPH to NAD+ [Homo sapiens]
releaseDate	2012-06-12
reverseReaction	[Reaction:1247649] AQP1 tetramer transports CO2 from cytosol to extracellular region [Homo sapiens] [Reaction:1237042] AQP1 tetramer transports CO2 from extracellular region to cytosol [Homo sapiens]
reviewed	[InstanceEdit:2207684] Jassal, B, 2012-04-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294743] R-HSA-1237042.4
summation	[Summation:1244356] Aquaporin-1 (AQP1) passively transports carbon dioxide (CO2)...
(hasEvent)	[Pathway:1237044] Erythrocytes take up carbon dioxide and release oxygen [Homo sapiens]
(precedingEvent)	[Reaction:1237325] Hemoglobin A is protonated and carbamated causing release of oxygen [Homo sapiens] [Reaction:1475435] CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- [Homo sapiens]
(reverseReaction)	[Reaction:1247649] AQP1 tetramer transports CO2 from cytosol to extracellular region [Homo sapiens]
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