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Details on Person Antigen processing by cathepsin S in endosoytic vesicle

Class:Id	Reaction:1236948
_displayName	Antigen processing by cathepsin S in endosoytic vesicle
_doRelease	TRUE
_timestamp	2018-01-03 21:10:58
authored	[InstanceEdit:1236976] Garapati, P V, 2011-03-28
catalystActivity	[CatalystActivity:1236936] cysteine-type endopeptidase activity of CTSS-like proteins [early endosome lumen]
catalystActivityReference	[CatalystActivityReference:9643987] cysteine-type endopeptidase activity of CTSS-like proteins [early endosome lumen] Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo
compartment	[Compartment:171907] endosome lumen
created	[InstanceEdit:1236957] Garapati, P V, 2011-03-28
edited	[InstanceEdit:1236976] Garapati, P V, 2011-03-28
inferredFrom	[Reaction:1236960] Processing of ovalbumin by cathepsin S [Gallus gallus]
input	[SimpleEntity:1236715] Exogenous soluble antigen [early endosome lumen]
isChimeric	FALSE
modified	[InstanceEdit:1295503] Garapati, P V, 2011-05-16 [InstanceEdit:1299495] Garapati, P V, 2011-05-23 [InstanceEdit:1307815] Garapati, P V, 2011-05-29 [InstanceEdit:1500890] Garapati, P V, 2011-08-22 [InstanceEdit:8943710] D'Eustachio, Peter, 2016-10-28 [InstanceEdit:9034322] Orlic-Milacic, Marija, 2018-01-03 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Antigen processing by cathepsin S in endosoytic vesicle
output	[SimpleEntity:8943711] L-amino acid [early endosome lumen] [SimpleEntity:1236722] precursor peptide fragment (>16 aa) [early endosome lumen]
precedingEvent	[Reaction:1236940] Exogenous soluble antigen targeted to more stable early endosome [Homo sapiens] [Reaction:1236955] Movement of clathrin coated vesicles into early endosome [Homo sapiens]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1295501] Desjardins, M, English, L, 2011-05-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1591356] R-HSA-1236948.5
summation	[Summation:1236594] Endocytic compartments contain many cysteine proteases such ...
(hasEvent)	[Pathway:1236977] Endosomal/Vacuolar pathway [Homo sapiens]
(precedingEvent)	[Reaction:1236954] Trimming of peptides by IRAP in endocytic vesicles [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782544] Update Tracker - [Reaction:1236948] Antigen processing by cathepsin S in endosoytic vesicle - v59:[add_removeOutput]
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No pathways have been reviewed or authored by Antigen processing by cathepsin S in endosoytic vesicle (1236948)