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Details on Person Peptides translocated back into the phagosomal lumen are loa...
| Class:Id | Summation:1236487 |
|---|---|
| _displayName | Peptides translocated back into the phagosomal lumen are loa... |
| _timestamp | 2011-04-27 13:05:12 |
| created | [InstanceEdit:1236587] Garapati, P V, 2011-03-28 |
| literatureReference | [LiteratureReference:1236405] ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells [LiteratureReference:1236473] Phagosomes are competent organelles for antigen cross-presentation |
| modified | [InstanceEdit:1252266] Garapati, P V, 2011-04-27 |
| text | Peptides translocated back into the phagosomal lumen are loaded onto MHC class I molecules. Guermonprez et al. (2003) detected the components of the peptide loading complex (TAP, tapasin, calreticulin and ERp57) together with MHC class I in purified early phagosomes. They observed peptide loading in the presence of ATP in purified phagosomes expressing HLA-A2, incubated with iodinated S-9-L peptide. From these experiments they concluded that TAP-imported peptides can be loaded on MHC class I molecules in the lumen of phagosomes. Houde et al. (2003) also observed OVA peptide SIINFEKL:MHC-I complex in the phagosome lumen. |
| (summation) | [BlackBoxEvent:1236962] Peptide loading on MHC class I in phagosome [Gallus gallus] [BlackBoxEvent:1236971] Peptide loading on MHC class I in phagosome [Homo sapiens] |
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No pathways have been reviewed or authored by Peptides translocated back into the phagosomal lumen are loa... (1236487)
