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Details on Person Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A)

Class:Id	Reaction:1234179
_displayName	Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A)
_doRelease	TRUE
_timestamp	2019-04-08 09:40:08
authored	[InstanceEdit:1234160] May, B, 2011-03-09
catalystActivity	[CatalystActivity:1234180] peptidyl-proline 4-dioxygenase activity of PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9644143] peptidyl-proline 4-dioxygenase activity of PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1234178] May, B, 2011-03-18
edited	[InstanceEdit:1234160] May, B, 2011-03-09
inferredFrom	[Reaction:1234177] Cytosolic PHD2,3 hydroxylates proline residues on HIF1A [Homo sapiens]
input	[EntityWithAccessionedSequence:1234119] EPAS1 [cytosol] [Homo sapiens] [SimpleEntity:29406] 2OG [cytosol] [SimpleEntity:29406] 2OG [cytosol] [SimpleEntity:29368] O2 [cytosol] [SimpleEntity:29368] O2 [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1233984] Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor [LiteratureReference:1234007] A gain-of-function mutation in the HIF2A gene in familial erythrocytosis [LiteratureReference:1233945] Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline [LiteratureReference:1234006] Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing [LiteratureReference:2255302] Prolyl hydroxylase PHD3 activates oxygen-dependent protein aggregation
modified	[InstanceEdit:1235001] May, B, 2011-03-19 [InstanceEdit:1235032] May, B, 2011-03-20 [InstanceEdit:2255297] May, B, 2012-05-19 [InstanceEdit:5253502] May, B, 2014-02-06 [InstanceEdit:9644144] May, Bruce, 2019-04-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A)
output	[EntityWithAccessionedSequence:1234149] 2xHP-EPAS1 [cytosol] [Homo sapiens] [SimpleEntity:29434] SUCCA [cytosol] [SimpleEntity:29434] SUCCA [cytosol] [SimpleEntity:113528] CO2 [cytosol] [SimpleEntity:113528] CO2 [cytosol]
precedingEvent	[BlackBoxEvent:480301] Expression of EPAS1 (HIF2A) [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2255300] Rantanen, Krista, 2012-05-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294722] R-HSA-1234179.3
summation	[Summation:1235017] Proline hydroxylases PHD2 (EGLN1) and PHD3 (EGLN3) located i...
(hasEvent)	[Pathway:1234176] Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha [Homo sapiens]
(precedingEvent)	[Reaction:1234183] Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha [Homo sapiens]
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