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Details on Person ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol

Class:IdBlackBoxEvent:1234175
_displayNameub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol
_doReleaseTRUE
_timestamp2016-07-25 20:47:09
authored[InstanceEdit:1234160] May, B, 2011-03-09
compartment[Compartment:70101] cytosol
[Compartment:7660] nucleoplasm
created[InstanceEdit:1234178] May, B, 2011-03-18
edited[InstanceEdit:1234185] May, B, 2011-03-18
input[Complex:1234103] ub-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:1233955] Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein
[LiteratureReference:1233961] Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein
[LiteratureReference:8932467] Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization
modified[InstanceEdit:1235001] May, B, 2011-03-19
[InstanceEdit:2255297] May, B, 2012-05-19
[InstanceEdit:5253502] May, B, 2014-02-06
[InstanceEdit:8932499] May, Bruce, 2016-07-25
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol
output[Complex:1234138] ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] [Homo sapiens]
precedingEvent
releaseDate2012-06-12
reviewed[InstanceEdit:2255300] Rantanen, Krista, 2012-05-19
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2294902] R-HSA-1234175.3
summation[Summation:1235011] When hypoxic cells return to normoxia, HIF-alpha is ubiquiti...
(hasEvent)[Pathway:1234176] Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha [Homo sapiens]
(precedingEvent)[BlackBoxEvent:1234159] Proteasome proteolyzes ub-HIF-alpha [Homo sapiens]
(updatedInstance)[_UpdateTracker:9782700] Update Tracker - [BlackBoxEvent:1234175] ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol - v58:[addLiteratureReference, modifyText]
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