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Details on Person Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity
| Class:Id | LiteratureReference:1234094 |
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| _displayName | Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity |
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| _timestamp | 2011-03-18 03:36:09 |
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| author | [Person:1233975] Lancaster, DE
[Person:189984] McNeill, LA
[Person:389582] McDonough, MA
[Person:1233992] Aplin, RT
[Person:1233966] Hewitson, KS
[Person:392087] Pugh, CW
[Person:392101] Ratcliffe, PJ
[Person:389606] Schofield, Christopher J |
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| created | [InstanceEdit:1233951] May, B, 2011-03-18 |
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| journal | Biochem J |
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| pages | 429-37 |
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| pubMedIdentifier | 15239670 |
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| title | Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity |
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| volume | 383 |
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| year | 2004 |
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| (literatureReference) | [Complex:1235007] FIH1:AscH-:Fe2+ dimer [cytosol] [Homo sapiens]
[CatalystActivityReference:9643080] 2-oxoglutarate-dependent dioxygenase activity of FIH1:AscH-:Fe2+ dimer [cytosol] Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases
[Reaction:1234164] Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) [Homo sapiens] |
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