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Details on Person p-6Y-EGFR L747_T751delinsP [plasma membrane]

Class:Id	EntityWithAccessionedSequence:1228042
_displayName	p-6Y-EGFR L747_T751delinsP [plasma membrane]
_timestamp	2018-11-08 14:53:02
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1228043] Orlic-Milacic, Marija, 2011-03-16
disease	[Disease:1247848] non-small cell lung carcinoma
endCoordinate	1210
hasModifiedResidue	[ModifiedResidue:182927] O4'-phospho-L-tyrosine at 1069 [ModifiedResidue:179797] O4'-phospho-L-tyrosine at 1092 [ModifiedResidue:179834] O4'-phospho-L-tyrosine at 1110 [ModifiedResidue:179844] O4'-phospho-L-tyrosine at 1172 [ModifiedResidue:179872] O4'-phospho-L-tyrosine at 1197 [ModifiedResidue:180321] O4'-phospho-L-tyrosine at 1016 [FragmentReplacedModification:9628407] Replacement of residues 747 to 751 by P
literatureReference	[LiteratureReference:1181048] EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
modified	[InstanceEdit:1247850] Orlic-Milacic, Marija, 2011-04-07 [InstanceEdit:1248671] Orlic-Milacic, Marija, 2011-04-11 [InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06 [InstanceEdit:9628416] Orlic-Milacic, Marija, 2018-11-08
name	p-6Y-EGFR L747_T751delinsP Phosphorylated Epidermal Growth Factor Receptor L747_T751delinsP p-6Y-EGFR Leu747_Thr751delinsPro
referenceEntity	[ReferenceGeneProduct:54208] UniProt:P00533 EGFR [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2018403] R-HSA-1228042.2
startCoordinate	25
(hasCandidate)	[CandidateSet:1182977] Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] [Homo sapiens] [CandidateSet:1182978] Phospho-EGFR L747_A750del spanning mutants [plasma membrane] [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9887837] Update Tracker - [EntityWithAccessionedSequence:1228042] p-6Y-EGFR L747_T751delinsP [plasma membrane] - v46:[modifyName] [_UpdateTracker:9899764] Update Tracker - [EntityWithAccessionedSequence:1228042] p-6Y-EGFR L747_T751delinsP [plasma membrane] - v67:[add_removeHasModifiedResidue]
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No pathways have been reviewed or authored by p-6Y-EGFR L747_T751delinsP [plasma membrane] (1228042)