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Details on Person EGFR L747_T751del [plasma membrane]

Class:Id	EntityWithAccessionedSequence:1228015
_displayName	EGFR L747_T751del [plasma membrane]
_timestamp	2021-08-13 20:57:08
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1228014] Orlic-Milacic, Marija, 2011-03-16
crossReference	[DatabaseIdentifier:1655508] COSMIC:COSM24432 [DatabaseIdentifier:1655504] COSMIC:COSV51766247
disease	[Disease:1247848] non-small cell lung carcinoma [Disease:1500689] cancer [Disease:1500699] lung cancer
endCoordinate	1210
hasModifiedResidue	[FragmentDeletionModification:9626695] Deletion of residues 747 to 751
literatureReference	[LiteratureReference:1181048] EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
modified	[InstanceEdit:1247850] Orlic-Milacic, Marija, 2011-04-07 [InstanceEdit:1248671] Orlic-Milacic, Marija, 2011-04-11 [InstanceEdit:1655512] Orlic-Milacic, Marija, 2011-10-12 [InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06 [InstanceEdit:9626696] Orlic-Milacic, Marija, 2018-10-29 [InstanceEdit:9750522] Orlic-Milacic, Marija, 2021-08-13
name	EGFR L747_T751del Epidermal Growth Factor Receptor L747_T751del EGFR Leu747_Thr751del
referenceEntity	[ReferenceGeneProduct:54208] UniProt:P00533 EGFR [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016926] R-HSA-1228015.3
startCoordinate	25
(hasCandidate)	[CandidateSet:1176052] Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane] [Homo sapiens] [CandidateSet:1182964] EGFR L747_A750del spanning mutants [plasma membrane] [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9887776] Update Tracker - [EntityWithAccessionedSequence:1228015] EGFR L747_T751del [plasma membrane] - v46:[modifyName] [_UpdateTracker:9900022] Update Tracker - [EntityWithAccessionedSequence:1228015] EGFR L747_T751del [plasma membrane] - v67:[add_removeHasModifiedResidue]
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No pathways have been reviewed or authored by EGFR L747_T751del [plasma membrane] (1228015)