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Details on Person EGFR L747_P753delinsS [plasma membrane]

Class:Id	EntityWithAccessionedSequence:1228010
_displayName	EGFR L747_P753delinsS [plasma membrane]
_timestamp	2018-11-08 14:19:10
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1228006] Orlic-Milacic, Marija, 2011-03-16
crossReference	[DatabaseIdentifier:1655492] COSMIC:COSM13564 [DatabaseIdentifier:1655498] COSMIC:COSV51767961
disease	[Disease:1247848] non-small cell lung carcinoma [Disease:1500689] cancer [Disease:1500699] lung cancer [Disease:1248679] head and neck squamous cell carcinoma [Disease:1655499] prostate cancer [Disease:1655494] prostate adenocarcinoma
endCoordinate	1210
hasModifiedResidue	[FragmentReplacedModification:9628403] Replacement of residues 747 to 753 by S
literatureReference	[LiteratureReference:1181035] Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
modified	[InstanceEdit:1247850] Orlic-Milacic, Marija, 2011-04-07 [InstanceEdit:1248671] Orlic-Milacic, Marija, 2011-04-11 [InstanceEdit:1655503] Orlic-Milacic, Marija, 2011-10-12 [InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06 [InstanceEdit:9628405] Orlic-Milacic, Marija, 2018-11-08
name	EGFR L747_P753delinsS Epidermal Growth Factor Receptor L747_P753delinsS EGFR Leu747_Pro753delinsSer EGFR L747_P753>S
referenceEntity	[ReferenceGeneProduct:54208] UniProt:P00533 EGFR [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016920] R-HSA-1228010.2
startCoordinate	25
(hasMember)	[CandidateSet:1176052] Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane] [Homo sapiens] [CandidateSet:1182964] EGFR L747_A750del spanning mutants [plasma membrane] [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9887799] Update Tracker - [EntityWithAccessionedSequence:1228010] EGFR L747_P753delinsS [plasma membrane] - v46:[modifyName] [_UpdateTracker:9899820] Update Tracker - [EntityWithAccessionedSequence:1228010] EGFR L747_P753delinsS [plasma membrane] - v67:[add_removeHasModifiedResidue]
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No pathways have been reviewed or authored by EGFR L747_P753delinsS [plasma membrane] (1228010)