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Details on Person Association of mature ERBB2 with HSP90 chaperone and its co-chaperone CDC37

Class:Id	Reaction:1227971
_displayName	Association of mature ERBB2 with HSP90 chaperone and its co-chaperone CDC37
_doRelease	FALSE
_timestamp	2024-03-20 23:45:50
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:1227968] Orlic-Milacic, Marija, 2011-03-14
input	[Complex:1225828] CDC37 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:372889] ERBB2 [plasma membrane] [Homo sapiens] [Complex:1221657] HSP90 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:1358718] ERBIN [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1227977] Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90 [LiteratureReference:1227978] Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex [LiteratureReference:1358720] ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor
modified	[InstanceEdit:1227985] Orlic-Milacic, Marija, 2011-03-15 [InstanceEdit:1247492] Orlic-Milacic, Marija, 2011-04-01 [InstanceEdit:2267358] Orlic-Milacic, M, 2012-05-24 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9634291] Orlic-Milacic, Marija, 2019-01-09 [InstanceEdit:9866055] Orlic-Milacic, Marija, 2024-03-20
name	Association of mature ERBB2 with HSP90 chaperone and its co-chaperone CDC37 ERBB2 + HSP90 homodimer + CDC37 homodimer => ERBB2:HSP90:CDC37
negativePrecedingEvent	[NegativePrecedingEvent:9866018] Futile Cycle: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 [NegativePrecedingEvent:9866009] Futile Cycle: ERBB2 homodimerization
output	[Complex:1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8914087] R-HSA-1227971.1
summation	[Summation:1227969] Mature ERBB2 requires continual association with HSP90 and C...
(hasEvent)	[Pathway:1227986] Signaling by ERBB2 [Homo sapiens]
(precedingEvent)	[Reaction:1227964] ERBB2 homodimerization [Homo sapiens] [Reaction:1918092] CHIP (STUB1) mediates ubiquitination of ERBB2 [Homo sapiens] [Reaction:1918095] CUL5 mediates ubiquitination of ERBB2 [Homo sapiens] [Reaction:1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 [Homo sapiens] [Reaction:9652264] ERBB2 binds TKIs [Homo sapiens] [Reaction:9652277] ERBB2 binds trastuzumab [Homo sapiens] [Reaction:9665726] ERBB2 binds pertuzumab [Homo sapiens]
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