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Details on Person ERBB2, present at low levels in normal cells, is overexpress...

Class:IdSummation:1227965
_displayNameERBB2, present at low levels in normal cells, is overexpress...
_timestamp2019-01-09 20:18:29
created[InstanceEdit:1227967] Orlic-Milacic, Marija, 2011-03-14
literatureReference[LiteratureReference:1227966] Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab
[LiteratureReference:1358720] ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor
[LiteratureReference:1227977] Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90
[LiteratureReference:1248735] Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation
modified[InstanceEdit:9634284] Orlic-Milacic, Marija, 2019-01-09
[InstanceEdit:9634291] Orlic-Milacic, Marija, 2019-01-09
[InstanceEdit:9634302] Orlic-Milacic, Marija, 2019-01-09
textERBB2, present at low levels in normal cells, is overexpressed in cancer cells with ERBB2 gene amplification, leading to growth factor-independent activation of ERBB2 signaling through formation of ERBB2 homodimers (Pickl and Ries 2009, Maadi et al. 2018). It is assumed that during homodimerization, similar to normal heterodimerization with ligand-activated ERBB family members, chaperone proteins HSP90 and CDC37, as well as ERBB2IP, dissociate from ERBB2 (Borg et al. 2000, Xu et al. 2001, Citri et al. 2004).
(summation)[Reaction:1227964] ERBB2 homodimerization [Homo sapiens]
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