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Details on Person ERBB2 homodimerization
Class:Id Reaction:1227964
_displayName ERBB2 homodimerization
_doRelease TRUE
_timestamp 2024-03-20 23:46:24
authored [InstanceEdit:9656339] Orlic-Milacic, Marija, 2019-07-31
compartment [Compartment:876] plasma membrane
created [InstanceEdit:1227967] Orlic-Milacic, Marija, 2011-03-14
disease [Disease:1500689] cancer
edited [InstanceEdit:9665760] Orlic-Milacic, Marija, 2019-11-01
input [Complex:1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] [Homo sapiens] [Complex:1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] [Homo sapiens]
isChimeric FALSE
literatureReference [LiteratureReference:1227966] Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab [LiteratureReference:9634297] The effects of trastuzumab on HER2-mediated cell signaling in CHO cells expressing human HER2
modified [InstanceEdit:1227972] Orlic-Milacic, Marija, 2011-03-14 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9634284] Orlic-Milacic, Marija, 2019-01-09 [InstanceEdit:9634291] Orlic-Milacic, Marija, 2019-01-09 [InstanceEdit:9634302] Orlic-Milacic, Marija, 2019-01-09 [InstanceEdit:9662688] Orlic-Milacic, Marija, 2019-09-23 [InstanceEdit:9665326] Orlic-Milacic, Marija, 2019-10-30 [InstanceEdit:9666039] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9666040] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9666041] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9666042] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9667512] Orlic-Milacic, Marija, 2019-11-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9866055] Orlic-Milacic, Marija, 2024-03-20
name ERBB2 homodimerization 2 x ERBB2:HSP90:CDC37 => ERBB2 homodimer
output [Complex:1227936] ERBB2 homodimer [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:1358718] ERBIN [plasma membrane] [Homo sapiens] [Complex:1225828] CDC37 [cytosol] [Homo sapiens] [Complex:1225828] CDC37 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:1358718] ERBIN [plasma membrane] [Homo sapiens] [Complex:1221657] HSP90 [cytosol] [Homo sapiens] [Complex:1221657] HSP90 [cytosol] [Homo sapiens]
precedingEvent
releaseDate 2019-12-10
reviewed [InstanceEdit:9662685] Kancha, Rama Krishna, 2019-09-16
reviewStatus [ReviewStatus:9821382] five stars
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:8914341] R-HSA-1227964.3
summation [Summation:1227965] ERBB2, present at low levels in normal cells, is overexpress...
(hasEvent) [Pathway:9634285] Constitutive Signaling by Overexpressed ERBB2 [Homo sapiens]
(precedingEvent) [Reaction:1248694] Trans-autophosphorylation of ERBB2 homodimer [Homo sapiens] [NegativePrecedingEvent:9866009] Futile Cycle: ERBB2 homodimerization
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