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Details on Person ERBB2 homodimerization

Class:IdReaction:1227964
_displayNameERBB2 homodimerization
_doReleaseTRUE
_timestamp2024-03-20 23:46:24
authored[InstanceEdit:9656339] Orlic-Milacic, Marija, 2019-07-31
compartment[Compartment:876] plasma membrane
created[InstanceEdit:1227967] Orlic-Milacic, Marija, 2011-03-14
disease[Disease:1500689] cancer
edited[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019-11-01
input[Complex:1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] [Homo sapiens]
[Complex:1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:1227966] Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab
[LiteratureReference:9634297] The effects of trastuzumab on HER2-mediated cell signaling in CHO cells expressing human HER2
modified[InstanceEdit:1227972] Orlic-Milacic, Marija, 2011-03-14
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:9634284] Orlic-Milacic, Marija, 2019-01-09
[InstanceEdit:9634291] Orlic-Milacic, Marija, 2019-01-09
[InstanceEdit:9634302] Orlic-Milacic, Marija, 2019-01-09
[InstanceEdit:9662688] Orlic-Milacic, Marija, 2019-09-23
[InstanceEdit:9665326] Orlic-Milacic, Marija, 2019-10-30
[InstanceEdit:9666039] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9666040] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9666041] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9666042] Orlic-Milacic, Marija, 2019-11-01
[InstanceEdit:9667512] Orlic-Milacic, Marija, 2019-11-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9866055] Orlic-Milacic, Marija, 2024-03-20
nameERBB2 homodimerization
2 x ERBB2:HSP90:CDC37 => ERBB2 homodimer
output[Complex:1227936] ERBB2 homodimer [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:1358718] ERBIN [plasma membrane] [Homo sapiens]
[Complex:1225828] CDC37 [cytosol] [Homo sapiens]
[Complex:1225828] CDC37 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:1358718] ERBIN [plasma membrane] [Homo sapiens]
[Complex:1221657] HSP90 [cytosol] [Homo sapiens]
[Complex:1221657] HSP90 [cytosol] [Homo sapiens]
precedingEvent
releaseDate2019-12-10
reviewed[InstanceEdit:9662685] Kancha, Rama Krishna, 2019-09-16
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8914341] R-HSA-1227964.3
summation[Summation:1227965] ERBB2, present at low levels in normal cells, is overexpress...
(hasEvent)[Pathway:9634285] Constitutive Signaling by Overexpressed ERBB2 [Homo sapiens]
(precedingEvent)[Reaction:1248694] Trans-autophosphorylation of ERBB2 homodimer [Homo sapiens]
[NegativePrecedingEvent:9866009] Futile Cycle: ERBB2 homodimerization
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No pathways have been reviewed or authored by ERBB2 homodimerization (1227964)