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Details on Person ITCH homolog downregulates MDA5/IPS1 signaling

Class:Id	Reaction:1227860
_displayName	ITCH homolog downregulates MDA5/IPS1 signaling
_doRelease	TRUE
_timestamp	2017-08-02 19:24:58
authored	[InstanceEdit:1168652] Shamovsky, V, 2011-01-04
catalystActivity	[CatalystActivity:1227826] ubiquitin-ubiquitin ligase activity of ITCH [cytosol]
compartment	[Compartment:17906] mitochondrial outer membrane [Compartment:70101] cytosol
created	[InstanceEdit:1227806] Shamovsky, V, 2011-03-10
edited	[InstanceEdit:1280191] Shamovsky, V, 2011-05-11
inferredFrom	[Reaction:990526] Recruitment of ITCH and K48 ubiquitination of MAVS [Homo sapiens]
input	[Complex:1227703] dsRNA:MDA5:IPS1 [mitochondrial outer membrane] [Gallus gallus] [Polymer:1227825] K48-linked polyubiquitin chain [cytosol] [Gallus gallus]
isChimeric	FALSE
literatureReference	[LiteratureReference:983448] PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4
modified	[InstanceEdit:1227902] Shamovsky, V, 2011-03-10 [InstanceEdit:1267862] Shamovsky, V, 2011-05-09 [InstanceEdit:1295510] Shamovsky, V, 2011-05-17 [InstanceEdit:1300654] Shamovsky, V, 2011-05-23 [InstanceEdit:9014711] Shamovsky, Veronica, 2017-08-02 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ITCH homolog downregulates MDA5/IPS1 signaling
output	[Complex:1227845] dsRNA:MDA5:IPS1:K48-pUb [mitochondrial outer membrane] [Gallus gallus]
relatedSpecies	[Species:9014381] Infectious bronchitis virus
releaseDate	2011-06-14
reviewed	[InstanceEdit:1295492] Garapati, P V, 2011-05-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:1357559] R-GGA-1227860.3
summation	[Summation:1267846] Predicted chicken ITCH shows 86% amino acid sequence identit...
(hasEvent)	[Pathway:1227888] Negative Regulation of MDA5 signaling [Gallus gallus]
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No pathways have been reviewed or authored by ITCH homolog downregulates MDA5/IPS1 signaling (1227860)