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Details on Person MEKK1 binds TRAF6

Class:Id	Reaction:1227778
_displayName	MEKK1 binds TRAF6
_doRelease	TRUE
_timestamp	2017-08-02 19:25:06
authored	[InstanceEdit:1168652] Shamovsky, V, 2011-01-04
compartment	[Compartment:17906] mitochondrial outer membrane [Compartment:70101] cytosol
created	[InstanceEdit:1227772] Shamovsky, V, 2011-03-10
edited	[InstanceEdit:1280191] Shamovsky, V, 2011-05-11
inferredFrom	[Reaction:933528] Interaction of MEKK1 with TRAF6 [Homo sapiens] [Reaction:933534] Interaction of MEKK1 with TRAF6 [Mus musculus]
input	[EntityWithAccessionedSequence:1227800] MEKK1 [cytosol] [Gallus gallus] [EntityWithAccessionedSequence:1227800] MEKK1 [cytosol] [Gallus gallus] [DefinedSet:1227773] dsRNA:MDA5:IPS1:K63-linked pUb TRAF6 or TRAF2 [mitochondrial outer membrane] [Gallus gallus]
isChimeric	FALSE
literatureReference	[LiteratureReference:933430] TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway [LiteratureReference:165931] MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta
modified	[InstanceEdit:1227902] Shamovsky, V, 2011-03-10 [InstanceEdit:1237399] Shamovsky, V, 2011-03-30 [InstanceEdit:1267866] Shamovsky, V, 2011-05-09 [InstanceEdit:1295510] Shamovsky, V, 2011-05-17 [InstanceEdit:1300654] Shamovsky, V, 2011-05-23 [InstanceEdit:9014711] Shamovsky, Veronica, 2017-08-02 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MEKK1 binds TRAF6
output	[Complex:1227776] dsRNA:MDA5:IPS1:K63-pUb-TRAF6/or TRAF2:MEKK1 [mitochondrial outer membrane] [Gallus gallus]
precedingEvent	[BlackBoxEvent:1227769] TRAF6/or TRAF2 ubiquitination within dsRNA:Mda5:Ips1:Traf6/ or Traf2 complex [Gallus gallus] [Reaction:1227775] TRAF6/or TRAF2 interacts with IPS-1 [Gallus gallus]
relatedSpecies	[Species:9014381] Infectious bronchitis virus
releaseDate	2011-06-14
reviewed	[InstanceEdit:1295492] Garapati, P V, 2011-05-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:1357611] R-GGA-1227778.3
summation	[Summation:1267833] Mammalian MEKK1 was reported to be involved to IPS-1/TRAF6 s...
(hasEvent)	[Pathway:1227892] TRAF6 mediated NF-kB activation [Gallus gallus]
(precedingEvent)	[Reaction:1227783] Phosphorylation of IKKs complex mediated by MEKK1 [Gallus gallus]
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